51091-84-0

Basic information

• Product Name: (S)-(+)-Naproxen chloride
• Synonyms: (S)-(+)-Naproxen chloride;(S)-2-(6-Methoxynaphthalen-2-yl)propanoyl chloride;(S)-(+)-Naproxen chloride >=97.0%
• CAS NO: 51091-84-0
• Molecular Formula: C₁₄H₁₃ClO₂
• Molecular Weight: 301.16516
• Mol File: 51091-84-0.mol
• Article Data: 69

Chemical Properties

• Melting Point: 94-96 °C
• Boiling Point: 371.6°Cat760mmHg
• Flash Point: 136.9°C
• Appearance: /
• Density: 1.206g/cm³
• Vapor Pressure: 1.02E-05mmHg at 25°C
• Refractive Index: 1.592
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (S)-(+)-Naproxen chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-Naproxen chloride(51091-84-0)
• EPA Substance Registry System: (S)-(+)-Naproxen chloride(51091-84-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36-52
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 51091-84-0(Hazardous Substances Data)

Usage

General Description

(S)-(+)-Naproxen chloride is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat pain, inflammation, and fever. It works by blocking the production of certain natural substances in the body that cause inflammation. Naproxen chloride is the active form of naproxen, and it is considered to be a more potent form of the drug. It is commonly used to relieve symptoms of conditions such as arthritis, menstrual cramps, tendonitis, and bursitis. The drug is generally considered safe when used as directed, but it can have side effects such as stomach upset, diarrhea, and dizziness. It should be used with caution in individuals with a history of stomach ulcers, kidney problems, or heart disease.

InChI:InChI=1/C14H13ClO2/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3/t9-/m0/s1

Upstream product

• 22204-53-1 (+)-2-(6-methoxy-2-naphthyl)propionic acid 
• 79-37-8 oxalyl dichloride 
• 22204-53-1 (2S)-2-(6-methoxy(2-naphthyl))propanoic acid 
• 26159-34-2 Naprelan 
• 7719-09-7 thionyl chloride 
• 32305-59-2 S-2-(6-methoxy-2-naphthyl)propionaldehyde 

Downstream Products

• 850494-54-1 (S)-2-(6-methoxynaphth-2-yl)-N-[(S)-1-(naphth-1-yl)ethyl]propionamide 
• 850494-55-2 (S)-2-(6-methoxynaphth-2-yl)-N-[(R)-1-(naphth-1-yl)ethyl]propionamide 
• 119991-61-6 (2S,αS)-methyl N-<2-(6-methoxy-2-naphthyl)propionyl>phenylalaninate 
• 264888-47-3 (S)-2-(6-Methoxy-naphthalen-2-yl)-propionic acid 3-(3-benzyloxy-6-hydroxy-2,4-dimethyl-phenyl)-3-methyl-butyl ester 
• 110599-11-6 2-(2-Hydroxyethoxy)ethyl 2-(6-methoxy-2-naphthyl)propionat 
• 100021-25-8 <1S-(1β,2α,3α,4β,5α)>-2,3-(dimethylmethylenedioxy)-5-<(S)-(2-(6-methoxy-2-naphthyl)propionyl)oxy>-4-<(phenylmethoxy)methyl>-1-cyclopentyl azide 
• 100101-49-3 (S)-2-(6-Methoxy-naphthalen-2-yl)-propionic acid (3aR,4S,5R,6R,6aS)-4-azido-6-benzyloxymethyl-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-5-yl ester 

Relevant articles and documents

Non-carboxylic Analogues of Aryl Propionic Acid: Synthesis, Anti-inflammatory, Analgesic, Antipyretic and Ulcerogenic Potential

As a part of ongoing studies in developing new potent anti-inflammatory and analgesic agents, a series of novel 6-methoxy naphthalene derivatives was efficiently synthesized and characterized by spectral and elemental analyses. The newly synthesized compounds were evaluated for their anti-inflammatory activities using carrageenin-induced rat paw edema model, analgesic activities using acetic acid induced writhing model in mice and anti-pyretic activity using yeast induced hyperpyrexia method as well as ulcerogenic effects. Among the synthesized compounds, thiourea derivative (6a, e) exhibited higher anti-inflammatory activity than the standard drug naproxen in reduction of the rat paw edema (88.71, 89.77%) respectively. All of the non-carboxylic tested compounds were found to have promising anti-inflammatory, analgesic and antipyretic activity, while were devoid of any ulcerogenic effects.

Chiral lewis acid-catalyzed highly enantioselective [4 + 3] cycloaddition reactions of nitrogen-stabilized oxyallyl cations derived from allenamides

A chiral Lewis acid-catalyzed highly enantioselective [4 + 3] cycloaddition reaction of allenamide-derived nitrogen-stabilized chiral oxyallyl cations is described here. The use of bisoxazoline ligand and CuOTf2 provides high enantioselectivity, especially with [SbF6]- as the counteranion. Copyright

S-(+)-naproxen chloride as acylating agent for separating the enantiomers of chiral amines and alcohols

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Esterase-activated release of naproxen from supramolecular nanofibres

Nanofibre forming peptide amphiphiles were conjugated to naproxen through an esterase-sensitive linker. The amount of naproxen released, in the presence of enzymes, was influenced by the linker conjugating the drug to the supramolecular assembly. In vitro studies showed the anti-inflammatory activity of the released drug was maintained. This journal is

Practical and sustainable approach for clean preparation of 5-organylselanyl uracils

An eco-friendly, sustainable and practical method for the efficient preparation of 5-organylselanyl uracils through the electrochemical selenylation of uracils and diorganyl diselenides at room temperature under oxidant- and external electrolyte-free cond

Visible-Light-Induced Radical Defluoroborylation of Trifluoromethyl Alkenes: An Access to gem-Difluoroallylboranes

A photoredox-catalyzed defluoroborylation of trifluoromethyl alkenes with N-heterocyclic carbene boranes is described for the synthesis of gem-difluoroallylboranes. This protocol exhibits a broad substrate scope and good functional group compatibility, which enables the late-stage functionalization of structurally complex compounds. Further transformations of the defluoroborylation products to valuable CF2-containing molecules are also demonstrated. (Figure presented.).