51125-16-7

Basic information

• Product Name: Benzene, 1-methoxy-4-(4-pentenyl)-
• Synonyms: p-4-pentenylanisole
• CAS NO: 51125-16-7
• Molecular Formula: C12H16O
• Molecular Weight: 176.258
• Mol File: 51125-16-7.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Benzene, 1-methoxy-4-(4-pentenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-methoxy-4-(4-pentenyl)-(51125-16-7)
• EPA Substance Registry System: Benzene, 1-methoxy-4-(4-pentenyl)-(51125-16-7)

Safety Data

• Hazardous Substances Data: 51125-16-7(Hazardous Substances Data)

Upstream product

• 594-19-4 tert.-butyl lithium 
• 303144-09-4 2-mesyloxy-5-(4-methoxyphenyl)-1-phenylsulfinylpentane 
• 38954-00-6 1-iodo-2-(4-methoxyphenyl)ethane 
• 125446-62-0 2-(4'-methoxyphenyl)ethyl magnesium iodide 
• 106-95-6 allyl bromide 
• 5162-44-7 1-bromo-4-butene 
• 824-94-2 p-methoxybenzyl chloride 
• 105-13-5 4-Methoxybenzyl alcohol 
• 52244-70-9 4-(4-methoxyphenyl)butan-1-ol 
• 391678-44-7 1-methoxy-4-(pent-4-yn-1-yl)benzene 
• 592-41-6 1-hexene 
• 14425-64-0 4-methoxyphenethyl bromide 
• 2622-05-1 allylmagnesium bromide 
• 113579-77-4 1-(4-methoxy-phenyl)-pent-4-en-1-ol 

Downstream Products

• 91304-38-0 2-[3-(4-methoxyphenyl)propyl]oxirane 
• 18657-10-8 (E)-1-methoxy-4-(pent-1-en-1-yl)benzene 
• 872-05-9 1-Decene 

Relevant articles and documents

Copper-catalyzed sp3-sp3 cross-coupling of turbo grignards with benzyl halides

The aromatic ring in benzyl halides and sulfonates imparts unique reactivity at the benzylic carbon atom. Photoredox sp3-sp3 cross-coupling proved ineffective for coupling p-methoxybenzyl chloride (PMBCl), leading to a new strategy for the sp3-sp3 cross-coupling of benzyl halides and sulfonates. This strategy involved LiCl-accelerated synthesis of a Grignard reagent followed by a copper-catalyzed cross-coupling. The conditions worked well for PMBCl due to its exceptional reactivity but other benzyl bromides or sulfonates reacted poorly.

Migratory Hydrogenation of Terminal Alkynes by Base/Cobalt Relay Catalysis

Migratory functionalization of alkenes has emerged as a powerful strategy to achieve functionalization at a distal position to the original reactive site on a hydrocarbon chain. However, an analogous protocol for alkyne substrates is yet to be developed. Herein, a base and cobalt relay catalytic process for the selective synthesis of (Z)-2-alkenes and conjugated E alkenes by migratory hydrogenation of terminal alkynes is disclosed. Mechanistic studies support a relay catalytic process involving a sequential base-catalyzed isomerization of terminal alkynes and cobalt-catalyzed hydrogenation of either 2-alkynes or conjugated diene intermediates. Notably, this practical non-noble metal catalytic system enables efficient control of the chemo-, regio-, and stereoselectivity of this transformation.

Aryltrifluoromethylative cyclization of unactivated alkenes by the use of PhICF3Cl under catalyst-free conditions

A concise and catalyst-free aryltrifluoromethylative cyclization of unactivated alkenes has been developed herein. The use of PhICF3Cl as a powerful trifluoromethylating agent allows easy transformations. A set of trifluoroethylated carbocycles and aza-hereocycles were efficiently synthesized in good yield and selectivity. A broad substrate scope, mild reaction conditions, and easy operation would make this method well-suited for applications.