51165-07-2

Basic information

• Product Name: SUBSTANCE P (6-11)
• Synonyms: HEXA-SUBSTANCE P;GLN-PHE-PHE-GLY-LEU-MET-NH2;H-GLN-PHE-PHE-GLY-LEU-MET-NH2;SUBSTANCE P (6-11);SUBSTANCE P FRAGMENT 6-11);SUBSTANCE-P-(-6-11) HEXA-SUBSTANCE P;[Gln6]substance P(6-11);L-Gln-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2
• CAS NO: 51165-07-2
• Molecular Formula: C₃₆H₅₂N₈O₇S
• Molecular Weight: 740.91
• Mol File: 51165-07-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 1198.9°C at 760 mmHg
• Flash Point: 678.9°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: -15°C
• CAS DataBase Reference: SUBSTANCE P (6-11)(CAS DataBase Reference)
• NIST Chemistry Reference: SUBSTANCE P (6-11)(51165-07-2)
• EPA Substance Registry System: SUBSTANCE P (6-11)(51165-07-2)

Safety Data

• Hazardous Substances Data: 51165-07-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C36H52N8O7S/c1-22(2)18-27(35(50)42-26(32(39)47)16-17-52-3)41-31(46)21-40-34(49)28(19-23-10-6-4-7-11-23)44-36(51)29(20-24-12-8-5-9-13-24)43-33(48)25(37)14-15-30(38)45/h4-13,22,25-29H,14-21,37H2,1-3H3,(H2,38,45)(H2,39,47)(H,40,49)(H,41,46)(H,42,50)(H,43,48)(H,44,51)/t25-,26-,27-,28-,29-/m0/s1

Upstream product

• 73994-96-4 Boc-Gly-Leu-Met-OMe 
• 72217-96-0 H-Leu-Met-OCH₃ 
• 2280-69-5 Boc-Leu-Met-OMe 
• 10332-17-9 Met-OMe 
• 83181-66-2 Boc-Phe-Phe-Gly-Leu-Met-OCH₃ 
• 101301-81-9 Boc-Gln-Phe-Phe-Gly-OMe 
• 64699-00-9 N-t-Boc-Gln-Phe-Phe-Gly-OH 
• 2131-00-2 leucyl-methionine amide hydrochloride 
• 2280-68-4 N-tert-butoxycarbonyl-L-leucyl-L-methioninamide 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 77511-06-9 t-butyloxycarbonyl-glutamyl-phenylalanyl-phenylalanine methyl ester 
• 77511-07-0 t-butyloxycarbonyl-glutamyl-phenylalanyl-phenylalanine 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 13082-29-6 L-phenylalanyl-L-phenylalanine methyl ester 

Downstream Products

• 109003-57-8 Z-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH₂ 
• 56104-22-4 pGlu-Gln-Phe-Phe-Gly-Leu-Met_.NH₂ 

Relevant articles and documents

Design, synthesis, and evaluation of substance P analogue with potential anti-pseudoallergic activity

Mast cells (MCs) are innate immune cells that can cause allergic reactions. Pseudo-allergic reactions are a type of reaction that have the clinical symptoms of an allergy without involving the IgE pathway of immune MCs. Some studies have found that the MR

SYNTHESIS OF HEXAPEPTIDES FRAGMENT OF SUBSTANCE P AND ITS PYROGLUTAMYL-ANALOG

Syntheses of Substance P, C-terminal hexapeptide fragment (Gln-Phe-Phe-Gly-Leu-Met-NH2), and its pyroglutamyl-analog which is formed as a by-product on decoupling step in synthesis of C-terminal hexapeptide fragment of substance P are described.