51285-13-3

Basic information

• Product Name: N'-Hydroxycyclopropanecarboximidamide
• Synonyms: AKOS B030098;N-HYDROXYCYCLOPROPANECARBOXAMIDINE;N'-HYDROXYCYCLOPROPANECARBOXIMIDAMIDE;Cyclopropanecarboximidamide, N-hydroxy- (9CI);N'-Hydroxycyclopropanecarboximideamide;Cyclopropanecarboxamide oxime;(Z)-N'-hydroxycyclopropanecarboxamidine;Cyclopropanecarboximidamide,N-hydroxy-
• CAS NO: 51285-13-3
• Molecular Formula: C₄H₈N₂O
• Molecular Weight: 100.12
• Product Categories: AMIDINE;OXIME;pharmacetical
• Mol File: 51285-13-3.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 176.0±23.0 °C(Predicted)
• Appearance: /
• Density: 1.50±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 15.04±0.20(Predicted)
• CAS DataBase Reference: N'-Hydroxycyclopropanecarboximidamide(CAS DataBase Reference)
• NIST Chemistry Reference: N'-Hydroxycyclopropanecarboximidamide(51285-13-3)
• EPA Substance Registry System: N'-Hydroxycyclopropanecarboximidamide(51285-13-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 51285-13-3(Hazardous Substances Data)

Usage

Uses

N''-Hydroxycyclopropanecarboximidamide

Upstream product

• 5500-21-0 cyclopropropanecarbonitrile 
• 6542-60-5 2-cyclopropylacetonitrile 

Downstream Products

• 137715-61-8 3-Amino-2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-thiophene 
• 1256699-22-5 ((3S,5S)-3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-5-(4-(trifluoromethyl)phenyl)piperidin-1-yl)(3-hydroxyazetidin-1-yl)methanone 
• 1256699-23-6 ((3R,5R)-3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-5-(4-(trifluoromethyl)phenyl)piperidin-1-yl)(3-hydroxyazetidin-1-yl)methanone 
• 1315367-01-1 C₁₁H₉BrN₂O 
• 1393843-02-1 2-(2-chloro-6-fluorophenyl)-7-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-4,4-dimethyl-1,4-dihydro-chromeno[3,4-d]imidazole 
• 1204300-52-6 4-{3-[1-(3-cyclopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]propoxy}-2-methylbenzoic acid methyl ester 
• 1165931-65-6 3-cyclopropyl-5-phenyl-1,2,4-oxadiazole 
• 1165931-66-7 4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)benzoic acid 
• 1165931-71-4 5-(4-bromobenzyl)-3-cyclopropyl-1,2,4-oxadiazole 
• 1165931-67-8 5-(2-chloro-5-nitrophenyl)-3-cyclopropyl-1,2,4-oxadiazole 
• 476302-34-8 5-benzyl-2-(3-cyclopropyl-[1,2,4]oxadiazol-5-ylmethylsulfanyl)-pyrimidin-4-ylamine 
• 135436-92-9 5-(2-aminophenyl)-3-cyclopropyl-1,2,4-oxadiazole 
• 133444-99-2 (3S,4R)-3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo<2.2.1>heptane 
• 133444-98-1 (3R,4R)-3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo [2.2.1]heptane 

Relevant articles and documents

BAX INHIBITORS AND USES THEREOF

A compound having formula (I) or (II) for use inhibiting Bax mediated cell death and/or apoptosis.

Design, synthesis and biological activities of piperidine-spirooxadiazole derivatives as α7 nicotinic receptor antagonists

α: 7 nicotinic acetylcholine receptors (nAChRs) expressed in the nervous and immune systems have been suggested to play important roles in the control of inflammation. However, the lack of antagonist tools specifically inhibiting α7 nAChR impedes the validation of the channel as therapeutic target. To discover a selective α7 antagonist, we started a pharmacophore-based virtual screening and identified a piperidine-spirooxadiazole derivative T761–0184 that acts as a α7 antagonist. A series of novel piperidine-spirooxadiazole derivatives were subsequently synthesized and evaluated using two-electrode voltage clamp (TEVC) assay in Xenopus oocytes. Lead compounds from two series inhibited α7 with their IC50 values ranging from 3.3 μM to 13.7 μM. Compound B10 exhibited α7 selectivity over other α4β2 and α3β4 nAChR subtypes. The analysis of structure-activity relationship (SAR) provides valuable insights for further development of selective α7 nAChR antagonists.

Continued exploration of 1,2,4-oxadiazole periphery for carbonic anhydrase-targeting primary arene sulfonamides: Discovery of subnanomolar inhibitors of membrane-bound hCA IX isoform that selectively kill cancer cells in hypoxic environment

An expanded set of diversely substituted 1,2,4-oxadiazole-containing primary aromatic sulfonamides was synthesized and tested for inhibition of human carbonic anhydrase I, II, IX and XII isoforms. The initial biochemical profiling revealed a significantly