51330-27-9 Usage
Description
Soyasaponin Bb is a triterpenoid saponin that has been found in soy and has enzyme inhibitory, antimetastatic, anti-inflammatory, and neuroprotective biological activities. It selectively inhibits human recombinant and porcine kidney renin (IC50s = 30 and 30 μg/ml, respectively) over bovine trypsin, human urinary kallikrein, and rabbit angiotensin converting enzyme (ACE) when used at a concentration of 100 μg/ml. Soyasaponin Bb inhibits the mouse brain sialyltransferase ST3GAL1 (Ki = 2.1 μM) and decreases levels of α2,3-linked sialic acid on the cell surface and decreases migration of B16/F10 mouse melanoma cells in vitro when used at a concentration of 75 μM. It also dose-dependently increases viability and mRNA expression of heme oxygenase-1 (HO-1) in BRL 3A immortalized rat hepatocytes subjected to alcohol-induced oxidative stress. Soyasaponin Bb (10 mg/kg per day) increases the latency to enter the dark chamber in a passive avoidance test and the percentage of spontaneous alterations in the Y-maze test in a rat model of learning and memory impairment induced by ibotenic acid .
Uses
Soyasaponin I has been used:to test its effect on migration and invasion of ovarian cancer cell linesas standard for the quantification of saponins from quinoa and fenugreek samplesas L-15 medium supplement for Zebrafish liver cell lines
General Description
Soyasaponin I is an oleanene-type triterpenoid aglycone and is a group B soyasaponin. It is an amphiphilic molecule and is metabolized by intestinal bacteria into sugars and aglycones.
Biochem/physiol Actions
Antioxidant and anti-inflammatory saponin found in soybean. Attenuates TNBS-induced colitis in mice. The structure consists of a glycoside moiety and triterpene derivative. Sialytransferase inhibitor and renin inhibitor.
Check Digit Verification of cas no
The CAS Registry Mumber 51330-27-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,3,3 and 0 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 51330-27:
(7*5)+(6*1)+(5*3)+(4*3)+(3*0)+(2*2)+(1*7)=79
79 % 10 = 9
So 51330-27-9 is a valid CAS Registry Number.
51330-27-9Relevant articles and documents
PLANT COMPOSITIONS ENRICHED IN DEHYDROSOYASAPONIN I (D-I) AND METHODS OF PRODUCING SUCH COMPOSITIONS
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Page/Page column 23-26; 32-35; 60-61; 66-68, (2008/12/07)
There is provided a method of producing a plant composition comprising dehydrosoyasaponin I (D-I), the method comprising the steps of extracting a plant flour with a solvent capable of extracting soyasaponins to produce an extract, and treating the extract with light. Also provided are compositions produced according to the method of the present invention.