51385-79-6

Basic information

• Product Name: diethyl (2-bromoethylidene)propanedioate
• CAS NO: 51385-79-6
• Molecular Formula: C₉H₁₃BrO₄
• Molecular Weight: 265.1011
• Mol File: 51385-79-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 256.8°C at 760 mmHg
• Flash Point: 109.1°C
• Density: 1.39g/cm³
• Vapor Pressure: 0.0151mmHg at 25°C
• Refractive Index: 1.487
• CAS DataBase Reference: diethyl (2-bromoethylidene)propanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl (2-bromoethylidene)propanedioate(51385-79-6)
• EPA Substance Registry System: diethyl (2-bromoethylidene)propanedioate(51385-79-6)

Safety Data

• Hazardous Substances Data: 51385-79-6(Hazardous Substances Data)

Upstream product

• 87-13-8 diethyl 2-ethoxymethylenemalonate 

Relevant articles and documents

A convenient synthesis of dialkyl 2-(2-haloethylidene)malonates, cyanoacetates and halocrotonates by one carbon extension

Abstract 2-Haloethylidenemalonates are highly reactive species and useful synthons for the synthesis of Famvir, an antiviral drug. Simple methods for the preparation of 2-haloalkylidenemalonates are not available. We have developed a novel and non-cumbersome methodology for the synthesis of dialkyl 2-(2-haloethylidene)malonates, cyanoacetates and halocrotonates by one carbon extension of dialkyl (2-alkoxymethylene)malonates, cyanoacetates and 3-alkoxyacrylates with dimethylsulfoxonium methylide.