51451-05-9Relevant articles and documents
Chemically synthesized heterocyclic insecticide intermediate and preparation method thereof
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Paragraph 0043, (2017/11/29)
The invention discloses a chemically synthesized heterocyclic insecticide intermediate and a preparation method thereof. The chemically synthesized heterocyclic insecticide intermediate is prepared from the following raw materials in parts by weight: 100 to 150 parts of distilled water, 65 to 90 parts of hydroxylamine sulphate, 80 to 100 parts of ammonia water, 20 to 30 parts of acetaldehyde, 30 to 40 parts of sodium hydroxide, 35 to 50 parts of potassium permanganate, 45 to 60 parts of concentrated hydrochloric acid and 15 to 20 parts of saturated salt water. According to the chemically synthesized heterocyclic insecticide intermediate, the preparation method is relatively mature and a technology is relatively simple; a production progress, and the dosage ratio of each index are convenient to control and the raw materials for synthesizing are materials which are common in the market and are cheap and easy to obtain; the yield of the prepared intermediate methylthioacetaldoxime reaches 75 percent to 80 percent and is much higher than the average yield of an existing market; the medicinal effect is improved; the intermediate methylthioacetaldoxime has stable chemical properties and does not have viscous decomposition or deterioration problems and the like at room temperature, and the economic benefits are improved.
MACROCYCLIC DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES
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Page/Page column 231-232, (2013/09/26)
The invention relates to compounds of formula (Φ) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to the uses thereof. The compounds and salts of the present invention inhibit anaplastic lymphoma kinase (ALK) and/or EML4-ALK and are useful for treating or ameliorating abnormal cell proliferative disorders, such as cancer.
3-(Arylthiomethyl)isoxazole-4,5-dicarboxamides: Chemoselective Nucleophilic Chemistry and Insecticidal Activity
Yu, Gui J.,Iwamoto, Satori,Robins, Lori I.,Fettinger, James C.,Sparks, Thomas C.,Lorsbach, Beth A.,Kurth, Mark J.
scheme or table, p. 7422 - 7426 (2010/07/08)
A collection of 91 3-(arylthiomethyl)isoxazole-4,5-dicarboxamides was prepared starting from dimethyl 3-(chloromethyl)isoxazole-4,5-dicarboxylate. The thioether moieties in these compounds were subsequently oxidized to give the corresponding 3-(arylsulfonylmethyl)isoxazole-4,5-dicarboxamides. By carefully controlling stoichiometry and reaction conditions, the C4 and C5 carbomethoxy groups could be differentially derivatized to carboxamides. A total of 182 trisubstituted isoxazoles are reported and deposited in the National Institutes of Health Molecular Repository; an 80 compound subset was evaluated for insecticidal activity.