51478-09-2

Basic information

• Product Name: 4-aza-androst-5(6)-ene-3,17-dione
• Synonyms: 4-aza-androst-5(6)-ene-3,17-dione
• CAS NO: 51478-09-2
• Molecular Formula: C₁₈H₂₅NO₂
• Molecular Weight: 287.3966
• Mol File: 51478-09-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-aza-androst-5(6)-ene-3,17-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-aza-androst-5(6)-ene-3,17-dione(51478-09-2)
• EPA Substance Registry System: 4-aza-androst-5(6)-ene-3,17-dione(51478-09-2)

Safety Data

• Hazardous Substances Data: 51478-09-2(Hazardous Substances Data)

Upstream product

• 6857-88-1 3-((3aS,5aS,6R,9aR,9bS)-3a,6-dimethyl-3,7-dioxododecahydro-1H-cyclopenta[a]naphthalen-6-yl)propanoic acid 
• 63-05-8 Androstenedione 
• 57-13-6 urea 

Downstream Products

• 98319-26-7 finasteride 
• 98319-24-5 dihydro-finasteride 

Relevant articles and documents

A 3-carbonyl-4-aza-5-androstene -17 β method for preparing derivatives of

The invention provides a preparation method of a 3-carbonyl-4-aza-5-androstene-17beta derivative. The preparation method comprises the following steps: suspending an A-nor-3,5-cracking-androstan-5-keto-3-carboxylic acid-17beta derivative II in an aqueous solution of ammonium acetate for performing a ring-closure reaction; cooling a reaction product; adjusting the PH value of the reaction product by using industrial ammonia water; filtering the reaction product by spinning; drying the reaction product by spinning; and washing a filter cake by using water, and drying the filter cake to obtain a 3-carbonyl-4-aza-5-androstene-17beta derivative I, wherein R in a formula II and a formula I is carbonyl, carboxylic acid, carboxylic ester, amide, acetyl, hydroxyl, alkyl, ether or chloro. The preparation method has the advantages of mild reaction condition in the absence of inorganic solvents, low requirements on equipment and pre-treatment, complete reaction, and high product purity of over 99 percent without purification; moreover, a spinning-filtered mother solution is recovered, so that the emission of three wastes is reduced greatly; in the whole reaction, used raw materials are readily available; and meanwhile, the reaction yield is high, and the preparation method is economical and environmentally friendly, and is convenient for industrial implementation.

A microwave promoted and Lewis acid catalysed solventless approach to 4-azasteroids

The preparation of 3-oxo-4-azasteroid from A-nor-3,5-secosteroid-3-oic acid is described in a solventless condition catalysed by Lewis acid under microwave irradiation. We utilized urea as an environmentally benign source for the generation of ammonia for the aza cyclization reaction.

4-aza steroids

The invention related to 4-aza-17β-(cyclopropoxy)-androst-5α-androstan-3-one, 4-aza-17β-(cyclopropylamino)-androst-4-en-3-one and related compounds and to compositions incorporating these compounds, as well as the inhibition of C17-20lyase, 5α-reductase and C17α-hydroxylase and to the use of these compounds in the treatment of androgen and estrogen mediated disorders, including benign prostatic hyperplasia, androgen mediated prostate cancer, estrogen mediated breast cancer and to DHT-mediated disorders such as acne. Disorders relating to the oversynthesis of cortisol, for example, Cushing's Syndrome, are also included. The treatment of androgen-dependent disorders also includes a combination therapy with known androgen-receptor antagonists, such as flutamide. The compounds of the invention have the following general formula: