515141-51-2 Usage
Uses
GW 803430 is a melanin-concentrating hormone receptor 1( MCH1) antagonist for treatment of obesity and depression.
Biochem/physiol Actions
GW-803430 antagonizes central MCHR1 and produces anxiolytic, anti-depressant and anti-obesity effects in rats and mice. It also controls the alcohol-seeking behavior in rats and is a promising treatment for alcohol use-related disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 515141-51-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,1,5,1,4 and 1 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 515141-51:
(8*5)+(7*1)+(6*5)+(5*1)+(4*4)+(3*1)+(2*5)+(1*1)=112
112 % 10 = 2
So 515141-51-2 is a valid CAS Registry Number.
515141-51-2Relevant articles and documents
The discovery and optimization of pyrimidinone-containing MCH R1 antagonists
Hertzog, Donald L.,Al-Barazanji, Kamal A.,Bigham, Eric C.,Bishop, Michael J.,Britt, Christy S.,Carlton, David L.,Cooper, Joel P.,Daniels, Alex J.,Garrido, Dulce M.,Goetz, Aaron S.,Grizzle, Mary K.,Guo, Yu C.,Handlon, Anthony L.,Ignar, Diane M.,Morgan, Ronda O.,Peat, Andrew J.,Tavares, Francis X.,Zhou, Huiqiang
, p. 4723 - 4727 (2007/10/03)
Optimization of a series of constrained melanin-concentrating hormone receptor 1 (MCH R1) antagonists has provided compounds with potent and selective MCH R1 activity. Details of the optimization process are provided and the use of one of the compounds in
