51533-65-4

Basic information

• Product Name: 4-CYANO-4-(3,4-DIMETHOXYPHENYL)CYCLOHEXANONE
• Synonyms: 4-CYANO-4-(3,4-DIMETHOXYPHENYL)CYCLOHEXANONE;1-(3,4-dimethoxyphenyl)-4-oxocyclohexanecarbonitrile
• CAS NO: 51533-65-4
• Molecular Formula: C₁₅H₁₇NO₃
• Molecular Weight: 259.303
• Mol File: 51533-65-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 439.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.16±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 4-CYANO-4-(3,4-DIMETHOXYPHENYL)CYCLOHEXANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CYANO-4-(3,4-DIMETHOXYPHENYL)CYCLOHEXANONE(51533-65-4)
• EPA Substance Registry System: 4-CYANO-4-(3,4-DIMETHOXYPHENYL)CYCLOHEXANONE(51533-65-4)

Safety Data

• Hazardous Substances Data: 51533-65-4(Hazardous Substances Data)

Upstream product

• 56326-94-4 methyl 5-cyano-5-(4-chlorophenyl)-2-oxocyclohexanecarboxylate 
• 127581-20-8 4-cyano-4-(3,4-dimethoxy-phenyl)-heptanedinitrile 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 735269-96-2 5-cyano-5-(3,4-dimethoxy-phenyl)-2-hydroxy-cyclohex-1-enecarboxylic acid methyl ester 
• 133648-53-0 methyl 5-cyano-5-(3,4-dimethoxyphenyl)-2-oxocyclohexanecarboxylate 
• 61749-05-1 methyl 5-cyano-5-(3,4-dimethoxyphenyl)-2-oxocyclohexanecarboxylate 
• 61330-09-4 dimethyl 4-cyano-4-(3,4-dimethoxyphenyl)heptanedioate 

Downstream Products

• 1160493-37-7 C₄₀H₄₀N₂O₈ 
• 29778-64-1 N-[2-(3,4-Dimethoxyphenyl)ethyl]-N-Methyl-4-cyano-4-(3,4-dimethoxyphenyl)-1-aminocyclohexane Hydrochloride 
• 121139-54-6 N-(2,3-Dihydro-1H-inden-1-yl)-N-methyl-4-(3,4-dimethoxyphenyl)-4-cyano-1-aminocyclohexane Hydrochloride 
• 854845-71-9 8-(3,4-dimethoxy-phenyl)-1,4-dioxa-spiro[4.5]decane 
• 133648-51-8 1-(3,4-dimethoxyphenyl)-t-4--N-methylamino>-r-1-cyclohexanecarbonitrile 
• 133648-48-3 1-(3,4-dimethoxyphenyl)-c-4--N-methylamino>-r-cyclohexanecarbonitrile 
• 735270-15-2 {2-[3-bromo-1-(3,4-dimethoxy-phenyl)-4-oxo-cyclohexyl]-ethyl}-methyl-carbamic acid benzyl ester 
• 735270-11-8 {2-[1-(3,4-dimethoxy-phenyl)-4-oxo-cyclohexyl]-ethyl}-methyl-carbamic acid benzyl ester 
• 735270-19-6 methanesulfonic acid 2-[9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl]-ethyl ester 
• 735270-17-4 {2-[1-(3,4-dimethoxy-phenyl)-4-oxo-cyclohex-2-enyl]-ethyl}-methyl-carbamic acid benzyl ester 
• 735270-07-2 {2-[9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl]-ethyl}-methyl-amine 
• 735270-05-0 2-[9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl]-ethanol 
• 735270-03-8 9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-9-vinyl-1,5-dioxa-spiro[5.5]undecane 
• 735270-01-6 9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undecane-9-carbaldehyde 

Relevant articles and documents

DI(HETERO)ARYLCYCLOHEXANE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM

The present invention relates to di(hetero)arylcyclohexane derivatives of the formula (I), in which Ar1, Ar2, R1 and R2 have the meanings indicated in the claims. The compounds of the formula (I) are valuable pharmaceutical active compounds which inhibit ATP-sensitive potassium channels in the heart muscle and are suitable, for example, for the treatment of disorders of the cardiovascular system such as arrhythmias or a decreased contractility of the heart, such as can occur, for example, in coronary heart disease, cardiac insufficiency or cardiomyopathies. In particular, they are suitable for the prevention of sudden cardiac death. The invention furthermore relates to processes and intermediates for the preparation of the compounds of the formula (I), their use and pharmaceutical compositions comprising them.

Verapamil analogues with restricted molecular flexibility

Three analogues with restricted flexibility were designed to study the active conformation of verapamil during interaction with the slow calcium channel. Thus cis- and trans-1-(3,4-dimethoxyphenyl)-4-[N-[2-(3,4-dimethoxyphenyl)ethyl]-N-me thylamino]-r-1-c

SYNTHESIS OF ALKALOIDS, TORTUOSAMINE, N-FORMYLTORTUOSAMINE, AND RELATED COMPOUND

Synthesis of alkaloids, tortuosamine, N-formyltortuosamine, and related compound, was accomplished by application of a new method constructing cycloalkenopyridines by thermal rearrangement of oxime O-allyl ethers as a key step