5159-41-1

Basic information

• Product Name: 2-Iodobenzyl alcohol
• Synonyms: 2-IODOBENZYL ALCOHOL;RARECHEM AL BD 0562;O-IODOBENZYL ALCOHOL;2-iodobenzylic alcohol;2-Iodobenzenemethanol.;BENZYLALCOHOL,ORTHO-IODO-;2-Iodophenylmethanol;2-Iodobenzyl alcohol,99%
• CAS NO: 5159-41-1
• Molecular Formula: C₇H₇IO
• Molecular Weight: 234.03
• EINECS: 225-933-2
• Product Categories: Benzhydrols, Benzyl & Special Alcohols;Alcohols;Iodine Compounds;C7 to C8;Oxygen Compounds
• Mol File: 5159-41-1.mol
• Article Data: 48

Chemical Properties

• Melting Point: 89-92 °C(lit.)
• Boiling Point: 145°C/10mmHg(lit.)
• Flash Point: 128.2 °C
• Appearance: White to yellow or pinkish/Needle-Like Powder
• Density: 1.7904 (estimate)
• Vapor Pressure: 0.00109mmHg at 25°C
• Refractive Index: 1.6349
• Storage Temp.: Store under Nitrogen
• PKA: 14.01±0.10(Predicted)
• Water Solubility: Insoluble in water.
• Sensitive: Light Sensitive
• BRN: 2079487
• CAS DataBase Reference: 2-Iodobenzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Iodobenzyl alcohol(5159-41-1)
• EPA Substance Registry System: 2-Iodobenzyl alcohol(5159-41-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/38-36/37/38
• Safety Statements: 22-24/25-37/39-26
• WGK Germany: 3
• F: 8-10
• Hazardous Substances Data: 5159-41-1(Hazardous Substances Data)

Usage

Chemical Properties

white to yellow or pinkish needle-like powder

Uses

Different sources of media describe the Uses of 5159-41-1 differently. You can refer to the following data:
1. 2-Iodobenzyl alcohol was used in the synthesis of substituted seven-membered lactones, 2-[(E)-(1?-iodo-2?-propenyl)]benzyl alcohol2 and 2,3-diphenyl-1-indenone.
2. 2-Iodobenzyl alcohol was used in the synthesis of: substituted seven-membered lactones2-[(E)-(1′-iodo-2′-propenyl)]benzyl alcohol2,3-diphenyl-1-indenone

Synthesis Reference(s)

The Journal of Organic Chemistry, 39, p. 3052, 1974 DOI: 10.1021/jo00934a028

InChI:InChI=1/C7H7IO/c8-7-4-2-1-3-6(7)5-9/h1-4,9H,5H2

Upstream product

• 26260-02-6 2-iodobenzaldehyde 
• 40400-13-3 2-Iodobenzyl bromide 
• 80953-51-1 (2-iodophenyl)methyl acetate 
• 5344-90-1 2-Aminobenzyl alcohol 
• 88-67-5 2-Iodobenzoic acid 
• 609-67-6 2-Iodobenzoyl chloride 
• 101290-83-9 Bis-<2-jod-phenylacetyl>-peroxid 
• 100-51-6 benzyl alcohol 
• 116599-64-5 2-dichloroiodanyl-benzyl alcohol 
• 64-19-7 acetic acid 
• 615-37-2 ortho-methylphenyl iodide 
• 62300-07-6 o-iodophenylacetyl chloride 
• 18698-96-9 o-iodophenylacetic acid 
• 52470-94-7 (2-iodophenyl)diazomethyl ketone 

Downstream Products

• 26260-02-6 2-iodobenzaldehyde 
• 4622-38-2 2-iodobenzyliodide 
• 116599-64-5 2-dichloroiodanyl-benzyl alcohol 
• 59473-45-9 2-(chloromethyl)iodobenzene 
• 40400-13-3 2-Iodobenzyl bromide 
• 126745-76-4 5-(2-Iodo-benzyloxy)-2-phenyl-4-trifluoromethyl-oxazole 
• 139557-85-0 Pent-4-enoic acid 2-iodo-benzyl ester 
• 126087-59-0 (2-Cyclohept-2-enyl-phenyl)-methanol 
• 126087-60-3 (2-Cyclohept-3-enyl-phenyl)-methanol 
• 126087-58-9 2-Cyclopent-2-eneylbenzyl alcohol 
• 161297-47-8 1-(2-Chloromethyl-allyloxymethyl)-2-iodo-benzene 
• 166757-00-2 <2-<2-(2-Methoxyphenyl)ethynyl>phenyl>methanol 
• 173986-53-3 2-Iodo-1-di-tert-butylsilyloxymethylbenzene 
• 166756-98-5 Methyl 2-<2-<2-(hydroxymethyl)phenyl>ethynyl>benzoate 

Relevant articles and documents

MACROCYCLIC COMPOUNDS USEFUL AS CHITINASE INHIBITORS

The present invention relates to macrocyclic compounds of formula (I) and their use as chitinase inhibitors as well as to pharmaceutical compositions and methods of preparation thereof. The compounds can in particular be used in the treatment, prevention and/or amelioration of asthma.

A General Method for Photocatalytic Decarboxylative Hydroxylation of Carboxylic Acids

A general and practical method for decarboxylative hydroxylation of carboxylic acids was developed through visible light-induced photocatalysis using molecular oxygen as the green oxidant. The addition of NaBH4 to in situ reduce the unstable peroxyl radical intermediate much broadened the substrate scope. Different sp3 carbon-bearing carboxylic acids were successfully employed as substrates, including phenylacetic acid-type substrates, as well as aliphatic carboxylic acids. This transformation worked smoothly on primary, secondary, and tertiary carboxylic acids.

Iodolopyrazolium Salts: Synthesis, Derivatizations, and Applications

The synthesis of iodolopyrazolium triflates via an oxidative cyclization of 3-(2-iodophenyl)-1H-pyrazoles is described. The reaction is characterized by a broad substrate scope, and various applications of these novel cyclic iodolium salts acting as useful synthetic intermediates are demonstrated, in particular in site-selective ring openings. This was finally applied to generate derivatives of the anti-inflammatory drug celecoxib. Their application as highly active halogen-bond donors is shown as well.