51627-47-5

Basic information

• Product Name: 2-MORPHOLINO-3-PYRIDINAMINE
• Synonyms: BUTTPARK 98\12-74;2-MORPHOLINO-3-PYRIDINAMINE;2-MORPHOLIN-4-YL-PYRIDIN-3-YLAMINE;AKOS B034185;3-Amino-2-morpholin-4-ylpyridine;2-Morpholinopyridin-3-amine
• CAS NO: 51627-47-5
• Molecular Formula: C₉H₁₃N₃O
• Molecular Weight: 179.22
• Mol File: 51627-47-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 127-129°C
• Boiling Point: 381.9 °C at 760 mmHg
• Flash Point: 184.8 °C
• Appearance: /
• Density: 1.208 g/cm³
• Vapor Pressure: 4.91E-06mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-MORPHOLINO-3-PYRIDINAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-MORPHOLINO-3-PYRIDINAMINE(51627-47-5)
• EPA Substance Registry System: 2-MORPHOLINO-3-PYRIDINAMINE(51627-47-5)

Safety Data

• Hazard Codes: Xi
• Statements: R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.; R36/37/38:Irritating to eyes, respiratory system
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl
• HazardClass: IRRITANT
• Hazardous Substances Data: 51627-47-5(Hazardous Substances Data)

Usage

General Description

2-Morpholino-3-pyridinamine is a chemical compound that belongs to the class of organic compounds known as pyridines and derivatives. It is a heterocyclic amine that contains a morpholine ring and a pyridine ring. 2-MORPHOLINO-3-PYRIDINAMINE has potential pharmacological properties and may be used in the development of drugs. It has a variety of potential applications, particularly in the field of medicinal chemistry. The exact properties and uses of 2-morpholino-3-pyridinamine may vary depending on its specific chemical structure and characteristics, but it is likely to have potential as a therapeutic agent or as a precursor in the synthesis of pharmaceuticals.

InChI:InChI=1/C9H13N3O/c10-8-2-1-3-11-9(8)12-4-6-13-7-5-12/h1-3H,4-7,10H2/p+1

Upstream product

• 5470-18-8 2-Chloro-3-nitropyridine 
• 110-91-8 morpholine 
• 6298-19-7 2-chloro-3-aminopyridine 
• 24255-27-4 4-(3-nitropyridin-2-yl)morpholine 
• 39856-57-0 2,6-dibromo-3-aminopyridine 

Relevant articles and documents

HDAC inhibitor and preparation method and application thereof

The present invention discloses a compound represented by a formula I, a stereoisomer thereof, and a pharmaceutically acceptable salt thereof. The invention further relates to a pharmaceutical composition containing the compound shown in the formula I and application of the compound in preparation of HDAC inhibitor drugs. The compound or the pharmaceutical composition thereof can be used for treating cell proliferation diseases, autoimmune diseases, inflammation, neurodegenerative diseases or viral diseases.

Design, synthesis and biological evaluation of new carbazole derivatives as anti-cancer and anti-migratory agents

Based on the efficacy of EHop-016 as an inhibitor of migration and Rac1 activation, a new series of carbazole derivatives has been synthesized. Cytotoxic and anti-migratory effects of these compounds were evaluated in MCF-7 and MDA-MB-231 breast cancer cell lines. Preliminary investigations of their anticancer activity demonstrated that several compounds have moderate antiproliferative effects on cancer cell lines with GI50 values in the range of 13–50 μM. Furthermore, compounds 3b and 11b inhibit migration activity of metastatic cell line MDA-MB-231 by 32% and 34%, respectively. Compound 11b was shown to inhibit activation of the Rho GTPase Rac1 by 55% at 250 nM in both MDA-MB-231 and MDA-MB-435 cell lines. Compared with the IC50 of Rac1 inhibition by lead compound EHop-016 of 1.1 μM, compound 11b demonstrates 4X improved in vitro efficacy.

The synthesis of 3-amino-2-dialkylaminopyridines

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