51649-80-0

Basic information

• Product Name: 5-AMINO-1-PHENYL-1H-PYRAZOLE-4-CARBOXYL&
• Synonyms: 5-AMINO-1-PHENYL-1H-PYRAZOLE-4-CARBOXYL&;5-Amino-1-phenyl-1H-pyrazole-4-carboxylic acid;5-Amino-1-phenylpyrazole-4-carboxylic acid;1H-Pyrazole-4-carboxylic acid, 5-amino-1-phenyl-;1-Phenyl-4-carboxy-5-aMinopyrazole;5-Amino-4-carboxy-1-phenyl-1H-pyrazole, (5-Amino-4-carboxy-1H-pyrazol-1-yl)benzene;5-Amino-1-phenyl-1H-pyrazole-4-carboxylic acid 97%;5-amino-1-phenyl-4-pyrazolecarboxylic acid
• CAS NO: 51649-80-0
• Molecular Formula: C₁₀H₉N₃O₂
• Molecular Weight: 203.2
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Pyrazoles
• Mol File: 51649-80-0.mol
• Article Data: 12

Chemical Properties

• Melting Point: 183-188 °C (dec.)(lit.)
• Boiling Point: 433.8 °C at 760 mmHg
• Flash Point: 216.2 °C
• Appearance: /
• Density: 1.41 g/cm³
• Vapor Pressure: 2.7E-08mmHg at 25°C
• Refractive Index: 1.679
• PKA: 4.49±0.10(Predicted)
• CAS DataBase Reference: 5-AMINO-1-PHENYL-1H-PYRAZOLE-4-CARBOXYL&(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-1-PHENYL-1H-PYRAZOLE-4-CARBOXYL&(51649-80-0)
• EPA Substance Registry System: 5-AMINO-1-PHENYL-1H-PYRAZOLE-4-CARBOXYL&(51649-80-0)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 26-36/37
• WGK Germany: 3
• TSCA: No
• Hazardous Substances Data: 51649-80-0(Hazardous Substances Data)

Usage

General Description

5-AMINO-1-PHENYL-1H-PYRAZOLE-4-CARBOXYL is a chemical compound with the molecular formula C10H9N3O2. It is a pyrazole derivative, which contains a phenyl group and an amino group. 5-AMINO-1-PHENYL-1H-PYRAZOLE-4-CARBOXYL& is commonly used in the synthesis of pharmaceuticals, agrochemicals, and dyes. It has been studied for its potential biological activities, such as its antimicrobial and anticancer properties. Additionally, it has been investigated for its potential use as a building block in organic chemistry reactions, due to its versatile and reactive nature.

InChI:InChI=1/C10H9N3O2/c11-9-8(10(14)15)6-12-13(9)7-4-2-1-3-5-7/h1-6H,11H2,(H,14,15)

Upstream product

• 100-63-0 phenylhydrazine 
• 62-53-3 aniline 
• 59-88-1 phenylhydrazine hydrochloride 
• 5334-43-0 5-Amino-4-cyano-1-phenylpyrazole 
• 16078-71-0 ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate 

Downstream Products

• 826-85-7 1-phenylpyrazol-5-amine 
• 51649-70-8 6-methyl-1-phenyl-1H-pyrazolo<3,4-d><1,3>oxazin-4(3H)-one 
• 117515-05-6 5-amino-1-phenyl-pyrazole-4-carbonyl chloride 

Relevant articles and documents

Synthesis of pyrazole-carboxamides and pyrazole-carboxylic acids derivatives: Simple methods to access powerful building blocks

Hybrid systems containing pyrazole moiety show a wide spectrum of biological activities. To access novel hybrids with pyrazole ring, in this work we synthesized twenty pyrazole-carboxylic acids and twenty pyrazole-carboxamides, using simple synthetic methods, to be used as building blocks in the development of new structures.

Discovery of novel multi-substituted benzo-indole pyrazole schiff base derivatives with antibacterial activity targeting DNA gyrase

The design and synthesis of novel multi-substituted benzo-indole pyrazole Schiff base derivatives of potent DNA gyrase inhibitory activity were the main aims of this study. All the novel synthesized compounds were examined for their antibacterial activities against Staphylococcus aureus, Listeria monocytogenes, Escherichia coli, and Salmonella. In addition, we selected 20 compounds for the in vitro antibacterial activities assay of 6 drug-resistant bacteria strains. The result revealed compound 8I-w exhibited excellent antibacterial activity against 4 drug-resistant E. coli bacteria strains with IC50 values of 7.0, 17.0, 13.5, and 1.0 μM, respectively. In vitro enzyme inhibitory assay showed that compound 8I-w displayed potent inhibition against DNA gyrase with IC50 values of 0.10 μM. The molecular docking model indicated that compounds 8I-w can bind well to the DNA gyrase by interacting with various amino acid residues. This study demonstrated that the compound 8I-w can act as the most potent DNA gyrase inhibitor in the reported series of compounds and provide valuable information for the commercial DNA gyrase inhibiting bactericides.

Pyrazolo pyrimidine derivative and its preparation method and application (by machine translation)

The invention discloses a pyrazolo pyrimidine ketone derivatives, wherein R1 For nicotinic acid, isonicotinic acid, 2 - chloro nicotinic acid, 6 - chloro nicotinic acid, 2 - bromo nicotinic acid, 6 - bromo nicotinic acid, 2 - fluoro nicotinic acid, 6 - fluoro nicotinic acid, 6 - methoxy nicotinic acid or 2 - methoxy nicotinic acid; R2 Hydrogen, fluoro, chloro or methyl; R3 Is hydrogen or methyl. Also disclosed the preparation method of the derivative and application, by chemical synthetic way to synthesize 40 for the purpose of the compound, and further by the introduction of the the purpose of the chiral compound to the secondary structure is optimized, so that the preparation of the pyrazole and pyrimidinone derivatives with broad-spectrum of cooperativity antifungal activity, in particular to the apple rot bacteria and germ inhibiting activity represent significant; the application in order to develop pyrazolo pyrimidine compound derivatives as the active ingredient to provide the basis for a novel bactericide. (by machine translation)