51690-50-7

Basic information

• Product Name: 4-methyl-3-phenylpentanoic acid
• Synonyms: 4-methyl-3-phenylpentanoic acid
• CAS NO: 51690-50-7
• Molecular Formula: C₁₂H₁₆O₂
• Molecular Weight: 192.25424
• Mol File: 51690-50-7.mol
• Article Data: 20

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-methyl-3-phenylpentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-3-phenylpentanoic acid(51690-50-7)
• EPA Substance Registry System: 4-methyl-3-phenylpentanoic acid(51690-50-7)

Safety Data

• Hazardous Substances Data: 51690-50-7(Hazardous Substances Data)

Upstream product

• 10321-71-8 4-methyl-pent-2-enoic acid 
• 71-43-2 benzene 
• 72277-17-9 (+/-)-ethyl 4-methyl-3-phenylpentanoate 
• 920-39-8 isopropylmagnesium bromide 
• 621-82-9 Cinnamic acid 
• 57181-82-5 4-bromo-isobutylbenzene 
• 14371-10-9 (E)-3-phenylpropenal 
• 611-70-1 phenyl isopropyl ketone 
• 104290-64-4 Z-4-methyl-3-phenyl-penta-2,4-dienoic acid 
• 77921-03-0 (E)-4-methyl-3-phenyl-2-pentenoic acid 
• 59771-18-5 diethyl 2-(2-methyl-1-phenylpropyl)malonate 
• 1068-55-9 isopropylmagnesium chloride 
• 140-10-3 (E)-3-phenylacrylic acid 
• 124-38-9 carbon dioxide 

Downstream Products

• 1019003-37-2 (R)-ethyl 4-methyl-3-phenylpentanoate 
• 22573-54-2 (R)-3-phenyl-4-methylpentanoic acid 
• 22573-51-9 (S)-(-)-3-phenyl-4-methylpentanoic acid 
• 72277-17-9 (+/-)-ethyl 4-methyl-3-phenylpentanoate 
• 1462940-80-2 (R)-2,3,5,6-tetrafluoro-4-methylbenzyl 4-methyl-3-phenylpentanoate 
• 1462940-81-3 (S)-2,3,5,6-tetrafluoro-4-methylbenzyl 4-methyl-3-phenylpentanoate 
• 20894-20-6 5,5-dimethyl-4-phenylpyrrolidin-2-one 
• 55001-06-4 acid γ-isopropyl γ-phenyl butirique 
• 55001-05-3 [1-(2-Bromo-ethyl)-2-methyl-propyl]-benzene 
• 126275-02-3 (+/-) α-(RS)-Cyano-3-phenoxybenzyl-4-methyl-3-phenylpentanoate 
• 83303-62-2 1-Diazo-5-methyl-4-phenyl-hexan-2-one 
• 199468-80-9 (S)-3-((2R,3S)-2-Azido-4-methyl-3-phenyl-pentanoyl)-4-phenyl-oxazolidin-2-one 
• 175853-65-3 (R)-3-((2S,3R)-2-Azido-4-methyl-3-phenyl-pentanoyl)-4-phenyl-oxazolidin-2-one 

Relevant articles and documents

Ruthenium-catalyzed intramolecular arene C(sp2)-H amidation for synthesis of 3,4-dihydroquinolin-2(1 H)-ones

We report the [Ru(p-cymene)(l-proline)Cl] ([Ru1])-catalyzed cyclization of 1,4,2-dioxazol-5-ones to form dihydroquinoline-2-ones in excellent yields with excellent regioselectivity via a formal intramolecular arene C(sp2)-H amidation. The reactions of the 2- and 4-substituted aryl dioxazolones proceeds initially through spirolactamization via electrophilic amidation at the arene site, which is para or ortho to the substituent. A Hammett correlation study showed that the spirolactamization is likely to occur by electrophilic nitrenoid attack at the arene, which is characterized by a negative ρ value of -0.73.

Construction of enantioenriched 9H-Fluorene frameworks via a cascade reaction involving remote vinylogous dynamic kinetic resolution

The benzylic C-H group of α,α-dicyanoolefins from 3-substituted 1-indanones could be significantly activated via transmission along the aromatic system, thus enabling dynamic kinetic resolution via a traditional reversible deprotonation- protonation process. Enantioenriched 9-substituted 9H-fluorene frameworks were finally constructed through an asymmetric vinylogous Michael addition to nitroolefins, followed by a cascade cyclization and oxidative aromatization process, under the catalysis of a chiral bifunctional thiourea-tertiary amine.

Stereoselective Sulfinyl Aniline-Promoted Pd-Catalyzed C?H Arylation and Acetoxylation of Aliphatic Amides

Stereoselective functionalization of aliphatic C?H bonds presents a great challenge. Following this target, we disclose herein an original strategy towards direct arylation of aliphatic chains at ?-methylene position based on a use of amide-sulfoxide bicoordinating directing group. Although moderate to high chiral induction (up to 9:1 d.r.) is achieved, diastereomerically pure compounds may be afforded by simple separation of diastereomeric products by silica gel chromatography. Accordingly, this reaction allows preparation of a large scope of high-value scaffolds in synthetically useful yields while recyclable character of our chiral auxiliary brings an additional benefit. A potential of this methodology to build up original molecules by sequential diarylation and expedient (two step) synthesis of a biologically active compound are further disclosed. Finally a first example of stereoselective direct acetoxylation of aliphatic chains is reported.