51753-57-2

Basic information

• Product Name: 7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-Benzodiazepin-2-one
• Synonyms: PHENAZEPAM;2H-1,4-BENZODIAZEPIN-2-ONE, 7-BROMO-5-(2-CHLOROPHENYL)-1,3-DIHYDRO-;7-BROMO-5-[O-CHLOROPHENYL]-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE;7-BROMO-5-(2-CHLORO-PHENYL)-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE;5-(2-Chlorophenyl)-7-bromo-1,4-benzodiazepin-2-one;IFLAB-BB F0133-0017;1,3-dihydro-7-bromo-5-(2-chlorophenyl)-2h-4-benzodiazepin-2-one;7-bromo-5-(2-chlorophenyl)-1,3-dihydro-2h-4-benzodiazepin-2-one
• CAS NO: 51753-57-2
• Molecular Formula: C₁₅H₁₀BrClN₂O
• Molecular Weight: 349.61
• EINECS: 200-835-2
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Psychopathic Drugs;Phenazepam ada@tuskwei.com whatsapp;8618031153937
• Mol File: 51753-57-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 214-224°C
• Boiling Point: 493 °C at 760 mmHg
• Flash Point: 2℃
• Appearance: White or off-white crystalline powder
• Density: 1.61 g/cm³
• Refractive Index: 1.691
• Storage Temp.: Controlled Substance, -20°C Freezer
• PKA: 11.58±0.70(Predicted)
• CAS DataBase Reference: 7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-Benzodiazepin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-Benzodiazepin-2-one(51753-57-2)
• EPA Substance Registry System: 7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-Benzodiazepin-2-one(51753-57-2)

Safety Data

• Hazard Codes: F,Xn
• Statements: 11-20/21/22-36
• Safety Statements: 16-36/37
• RIDADR: UN 1648 3 / PGII
• WGK Germany: 2
• Hazardous Substances Data: 51753-57-2(Hazardous Substances Data)

Usage

Description

Phenazepam (CRM) (Item No. ISO60172) is a certified reference material categorized as a benzodiazepine. It has sedative and hypnotic properties and has been detected in illicit tablets. This product is intended for research and forensic applications.

Chemical Properties

7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-Benzodiazepin-2-one is Pale Yellow Solid

Uses

7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-Benzodiazepin-2-one is used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal and insomnia. It can be used as a premedication before surgery as it augments the effects of anesthetics and reduces anxiety

General Description

Phenazepam, a benzodiazepine drug produced in Russia, is used in Europe as an anxiolytic, anticonvulsant, and muscle relaxant. Although not used therapeutically in the US, the drug can be purchased on the internet for “laboratory research” purposes. Cases of abuse have been reported from European countries such as Sweden and Russia to states including New York, Kentucky, North Carolina, and Georgia.

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Clí, Brí, and NOx.

InChI:InChI=1/C15H8BrClN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-8H

Upstream product

• 598-21-0 2-Bromoacetyl bromide 
• 60773-49-1 (2-amino-5-bromophenyl)(2-chlorophenyl)methanone 
• 16437-59-5 phthalic acid hydrazide 
• 87213-48-7 5-bromo-2'-chloro-2-(phthalimidoacetamido)benzophenone 

Downstream Products

• 130788-49-7 7-bromo-3-hydroxy-1-carboxymethyl-5-(o-chlorophenyl)-1,2-dihydro-3H-1,4-benzdiazepin-2-one 
• 130788-50-0 7-bromo-1-tert-butyloxycarbonylmethyl-3-hydroxy-5-(o-chlorophenyl)-1,2-dihydro-3H-1,4-benzdiazepin-2-one 
• 130788-51-1 3-acetoxy-7-bromo-1-tert-butyloxycarbonylmethyl-5-(o-chlorophenyl)-1,2-dihydro-3H-1,4-benzdiazepin-2-one 
• 87213-50-1 8-bromo-5-(2-chlorophenyl)-1-methyl-4H-s-triazolo<4,3-a>-1,4-benzodiazepine 
• 1072906-57-0 C₂₂H₁₃Br₂ClN₂O 
• 1072906-65-0 C₂₄H₁₉BrClN₃O 
• 1072906-59-2 C₂₂H₁₃Br₂ClN₂O 
• 1072906-56-9 C₂₂H₁₄BrClN₂O 
• 1072906-67-2 C₂₅H₂₀BrClN₂O₄ 
• 1072906-63-8 C₂₂H₁₃BrClN₃O₃ 
• 1072906-60-5 C₂₂H₁₃BrCl₂N₂O 
• 1072906-61-6 C₂₂H₁₃BrClFN₂O 
• 1072906-58-1 C₂₂H₁₃Br₂ClN₂O 
• 1072906-62-7 C₂₁H₁₃BrClN₃O 

Relevant articles and documents

Stereospecific anxiolytic and anticonvulsant agents with reduced muscle-relaxant, sedative-hypnotic and ataxic effects

The present invention provides compositions and methods of using stereospecific benzodiazepine derivatives, their salts and prodrugs for the treatment of anxiolytic or convulsant disorders having the side effects of reduced alcohol craving in human alcoholics and a concomitant reduced sedative, hypnotic, muscle relaxant and ataxic side-effects. The invention further provides pharmaceutical compositions for treatment of anxiolytic and convulsant disorders in subjects in need thereof, comprising a compound, prodrug or a salt having a chemical structure represented by any one of Formula I-XXI and a pharmaceutically-acceptable carrier.

Synthesis of two 1-substituted 8-bromo-6-(2-chlorophenyl)-4H-s-triazolo[4,3-a]-1,4-benzodiazepines

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