51799-32-7 Usage
General Description
d-N-propylamphetamine, also known as NPA, is a psychoactive drug and member of the amphetamine class. It is a substituted amphetamine with a longer propyl group attached to the nitrogen atom, which affects its potency and duration of action. NPA is a dopamine and norepinephrine releasing agent, leading to increased levels of these neurotransmitters in the brain. It has been studied for potential use in the treatment of attention-deficit/hyperactivity disorder (ADHD) and narcolepsy, but its use is limited due to its potential for abuse and addiction. NPA is also a controlled substance in many countries due to its psychoactive effects and abuse potential. Overall, NPA is a chemical with stimulant properties that has both therapeutic potential and recreational abuse risks.
Check Digit Verification of cas no
The CAS Registry Mumber 51799-32-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,7,9 and 9 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 51799-32:
(7*5)+(6*1)+(5*7)+(4*9)+(3*9)+(2*3)+(1*2)=147
147 % 10 = 7
So 51799-32-7 is a valid CAS Registry Number.
InChI:InChI=1/C12H19N/c1-3-9-13-11(2)10-12-7-5-4-6-8-12/h4-8,11,13H,3,9-10H2,1-2H3
51799-32-7Relevant articles and documents
Quantitative structure-activity relationships in drug metabolism and disposition: Pharmacokinetics of N-substituted amphetamines in humans
Testa,Salvesen
, p. 497 - 501 (2007/10/02)
Pharmacokinetic data of 15 N-alkyl-substituted amphetamines in humans have been the object of a retrospective quantitative structure-activity relationship study. The urinary excretion of amphetamines was shown to decrease with increasing lipophilicity; the correlation equations revealed that, for identical lipophilicities, tertiary amines are excreted faster than secondary amines, which are secreted faster than primary amines. The apparent n-heptane-pH 7.4 buffer partition coefficient correlates better with urinary excretion than does the true n-octanol-water partition coefficient, probably because it includes a pKa term that accounts for the fraction of the drug present in the tubules as nonionic species. The N-dealkylation rate increases with increasing lipophilicity of the substrates (enhanced enzyme affinity) but decreases with increasing bulk of the N-substituent that is split off (steric hindrance of initial C(α)-hydroxylation.
