518348-13-5

Basic information

• Product Name: 2H-Pyran-2-one,tetrahydro-4-hydroxy-5-methyl-6-(1-methylethyl)-,(4R,5S,6R)-rel-(9CI)
• Synonyms: 2H-Pyran-2-one,tetrahydro-4-hydroxy-5-methyl-6-(1-methylethyl)-,(4R,5S,6R)-rel-(9CI)
• CAS NO: 518348-13-5
• Molecular Formula: C9H16O3
• Molecular Weight: 172.22154
• Product Categories: ISOPROPYL
• Mol File: 518348-13-5.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2H-Pyran-2-one,tetrahydro-4-hydroxy-5-methyl-6-(1-methylethyl)-,(4R,5S,6R)-rel-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyran-2-one,tetrahydro-4-hydroxy-5-methyl-6-(1-methylethyl)-,(4R,5S,6R)-rel-(9CI)(518348-13-5)
• EPA Substance Registry System: 2H-Pyran-2-one,tetrahydro-4-hydroxy-5-methyl-6-(1-methylethyl)-,(4R,5S,6R)-rel-(9CI)(518348-13-5)

Safety Data

• Hazardous Substances Data: 518348-13-5(Hazardous Substances Data)

Upstream product

• 115560-90-2 (2R)-(E)-1-(phenylmethoxy)-4-hexen-2-ol 
• 1030599-26-8 (3R,4R,5R)-4,6-dimethylheptane-1,3,5-triol 
• 93215-51-1 1-tert-butoxy-1-(trimethylsiloxy)ethylene 
• 116660-67-4 (2S,3R)-3-<(tert-Butyldimethylsilyl)oxy>-2,4-dimethylpentanal 
• 72324-46-0 6-ethyl-2,2-dimethyl-2H,4H-1,3-dioxin-4-one 
• 1268671-75-5 C₁₉H₃₁NO₄ 
• 1268671-74-4 C₁₇H₂₇NO₄ 
• 1268671-69-7 (5S,6S)-dihydro-6-isopropyl-5-methyl-3H-pyran-2,4-dione 
• 1268671-73-3 (1R,2S,5R)-5-methyl-2-(2-phenylpropan-2-yl)cyclohexyl 3-oxopentanoate 
• 1268671-98-2 (1S,2R,4R)-1-(methoxyphenylmethyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-yl (E)-3-(pyrrolidin-1-yl)pent-2-enoate 
• 1268671-97-1 (1S,2R,4R)-1-(hydroxydiphenylmethyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-yl (E)-3-(pyrrolidin-1-yl)pent-2-enoate 
• 1268671-96-0 (1S,2R,4R)-7,7-dimethylbicyclo[2.2.1]heptane-1-carboxylic acid phenylamid-2-yl (E)-3-(pyrrolidin-1-yl)pent-2-enoate 
• 1268671-95-9 (1R,2R,4R)-1-(diphenylaminomethyl)-7,7-dimethylbicyclo[2.2.1]hept-2-yl (E)-3-(pyrrolidin-1-yl)pent-2-enoate 
• 1268671-94-8 (1R,2R,4R)-1-(diisopropylaminomethyl)-7,7-dimethylbicyclo[2.2.1]hept-2-yl (E)-3-(pyrrolidin-1-yl)pent-2-enoate 

Relevant articles and documents

Enantioselective synthesis of prelactone B using a proline-catalyzed crossed-aldol reaction

Catalytic enantioselective synthesis of prelactone B has been achieved in only four steps. A direct proline-catalyzed aldehyde-aldehyde aldol reaction is employed as the sole source of chirality.

Total syntheses of Prelactone V and Prelactone B

The total syntheses of natural products Prelactone-V and Prelactone-B have been accomplished by a novel Chiron approach starting from D-glucose. The synthesis involves isopropylidene acetal formation of D-glucose using Poly(4-vinylpyridine) supported iodine as a catalyst, Tebbe olefination, Grignard reaction, Wittig olefination, selective mono deprotection of acetal using PMA/SiO2, hydrogenation and anti-1,3-diol formation are as key steps.

Asymmetric synthesis of chiral δ-lactones containing multiple contiguous stereocenters

A versatile methodology for the asymmetric synthesis of chiral δ-lactones containing multiple contiguous stereocenters has been developed that relies on a series of Evans' aldol, hydroxyl-directed cyclopropanation, methanolysis, and Hg(II) mediated cyclopropane ring-opening reactions for stereocontrol.

Application of silacyclic allylsilanes to the synthesis of β-hydroxy-δ-lactones: synthesis of Prelactone B

Silacyclic allylsilanes generated through a silene-diene Diels-Alder cycloaddition represent versatile bifunctional reagents for organic synthesis. This is demonstrated in a short stereocontrolled synthesis of (±)-Prelactone B.