518358-60-6

Basic information

• Product Name: N-[(4S,5S)-4-(biphenyl-4-yl)-2,2-dimethyl-1,3-dioxan-5-yl]propane-1-sulfonamide
• Synonyms: N-[(4S,5S)-4-(biphenyl-4-yl)-2,2-dimethyl-1,3-dioxan-5-yl]propane-1-sulfonamide
• CAS NO: 518358-60-6
• Molecular Weight: 389.516
• Mol File: 518358-60-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-[(4S,5S)-4-(biphenyl-4-yl)-2,2-dimethyl-1,3-dioxan-5-yl]propane-1-sulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(4S,5S)-4-(biphenyl-4-yl)-2,2-dimethyl-1,3-dioxan-5-yl]propane-1-sulfonamide(518358-60-6)
• EPA Substance Registry System: N-[(4S,5S)-4-(biphenyl-4-yl)-2,2-dimethyl-1,3-dioxan-5-yl]propane-1-sulfonamide(518358-60-6)

Safety Data

• Hazardous Substances Data: 518358-60-6(Hazardous Substances Data)

Upstream product

• 10147-36-1 n-propanesulfonyl chloride 
• 212195-36-3 (4S,5S)-4-(biphenyl-4-yl)-2,2-dimethyl-1,3-dioxan-5-amine 
• 212195-34-1 1-Biphenyl-4-yl-2-diallylamino-propane-1,3-diol 
• 3218-36-8 4-Phenylbenzaldehyde 
• 101293-94-1 methyl rac-2-amino-3-(biphenyl-4-yl)-3-hydroxypropanoate 
• 212195-32-9 3-Biphenyl-4-yl-3-(tert-butyl-dimethyl-silanyloxy)-2-diallylamino-propionic acid methyl ester 

Downstream Products

• 212195-45-4 (R)-1-Phenyl-butane-2-sulfonic acid ((4S,5S)-4-biphenyl-4-yl-2,2-dimethyl-[1,3]dioxan-5-yl)-methyl-amide 
• 212195-44-3 (3R)-N-[(4S,5S)-4-(biphenyl-4-yl)-2,2-dimethyl-1,3-dioxan-5-yl]-N-methylheptane-3-sulfonamide 
• 212195-40-9 N-[(4S,5S)-4-(biphenyl-4-yl)-2,2-dimethyl-1,3-dioxan-5-yl]-N-methylpropane-1-sulfonamide 

Relevant articles and documents

Enantioselective synthesis of α-substituted N-methyl-sulfonamides

The first asymmetric α-alkylations of lithiated sulfonamides bearing the chirality information within the amine moiety under high asymmetric inductions (de 83-95 %) are described. Racemization-free acidic hydrolysis led to the title compounds 11 in acceptable overall yields and with high enantiomeric purity (ee 91- ≤98%; Scheme 2). As a novel chiral auxiliary, the primary amine (S,S)- or (R,R)-2 was synthesized employing the classical Erlenmeyer phenylserine synthesis (Schone I).