5198-79-8Relevant articles and documents
Method for preparing 2-chloro-1,3-thiazole-5-formaldehyde
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Paragraph 0023; 0024, (2019/05/08)
The invention discloses a method for preparing 2-chloro-1,3-thiazole-5-formaldehyde. The method comprises the following steps: in the presence of lithium diisopropylamide, carrying out a reaction between 2-chlorothiazole shown in (I) and compounds shown in a formula (II) or compounds shown in a formula (IV) under the condition of low temperature to obtain the 2-chloro-1,3-thiazole-5-formaldehyde shown as a formula (III) (The formula is shown in the specification). In the formula (II), substituent groups R1 and R2 are respectively and separately selected from C1 to C4 alkyls; in the formula (IV), X represents C or O element. According to the method disclosed by the invention, the 2-chloro-1,3-thiazole-5-formaldehyde can be prepared by using the lithium diisopropylamide in wider temperaturerange at higher yield; in addition, the method is not reported in literature; the lithium diisopropylamide has better dehydrogenation selectivity and cannot react with carbonyl.