51985-95-6

Basic information

• Product Name: 5-HYDROXY-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER
• Synonyms: 1-Methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylic acid methyl ester;Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate 97%;Methyl 5-hydroxy-1-methyl-3-pyrazolecarboxylate;NSC 338308;5-HYDROXY-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER ;1H-Pyrazole-3-carboxylic acid, 1-methyl-, methyl ester;Methyl 5-hydroxy-1-Methyl-1H-pyrazole-3-carboxylate;Methyl 1-Methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate
• CAS NO: 51985-95-6
• Molecular Formula: C₆H₈N₂O₃
• Molecular Weight: 156.13932
• Mol File: 51985-95-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 195-200°C
• Boiling Point: 330.7 °C at 760 mmHg
• Flash Point: 153.8 °C
• Appearance: /
• Density: 1.35 g/cm³
• Vapor Pressure: 0.0659mmHg at 25°C
• Refractive Index: 1.508
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.26±0.28(Predicted)
• CAS DataBase Reference: 5-HYDROXY-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-HYDROXY-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER(51985-95-6)
• EPA Substance Registry System: 5-HYDROXY-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER(51985-95-6)

Safety Data

• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 51985-95-6(Hazardous Substances Data)

Usage

General Description

The chemical 5-HYDROXY-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER is a methyl ester derivative of 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylic acid. It is a heterocyclic compound that contains a pyrazole ring with a hydroxyl group and a methyl ester. 5-HYDROXY-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER has potential pharmaceutical applications and is used in research and development of new drugs. Its properties and potential uses make it an important chemical in the field of medicinal chemistry.

InChI:InChI=1/C6H8N2O3/c1-8-5(9)3-4(7-8)6(10)11-2/h3,7H,1-2H3

Upstream product

• 58364-79-7 2-(1-Methylhydrazino)maleinsaeure-dimethylester 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 60-34-4 methylhydrazine 
• 246539-64-0 ethyl methoxalylacetate 
• 70609-03-9 2-(1-Methylhydrazino)maleinsaeure-6>dimethylester 

Downstream Products

• 180519-10-2 (5-methoxy-1-methyl-1H-pyrazol-3-yl)methanol 
• 1617523-10-0 5-bromo-N-(2,6-difluorophenyl)-1-methyl-1H-pyrazole-3-carboxamide 
• 1617522-52-7 5-(2,5-dimethoxyphenyl)-1-methyl-N-(3-methyl-pyridin-4-yl)-1H-pyrazole-3-carboxylic acid amide 
• 1617522-35-6 5-(2,5-dimethoxyphenyl)-N-(2-fluoro-4-methylsulfonyl-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide 
• 1617523-36-0 C₂₀H₁₇F₂N₃O₄ 
• 1617523-35-9 C₁₅H₁₆N₂O₅ 
• 1617523-52-0 C₁₃H₁₁F₃N₂O₂ 
• 1177228-47-5 C₁₃H₁₄N₂O₄ 
• 1456071-47-8 C₁₄H₁₆N₂O₄ 
• 1617522-84-5 N-(2,6-difluoro-phenyl)-5-(2,5-dimethoxyphenyl)-4-(hydroxymethyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide 
• 1617521-89-7 N-(2,4-difluoro-phenyl)-5-(2,5-dimethoxyphenyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide 
• 1617522-72-1 N-(2,6-difluoro-4-methoxy-phenyl)-5-(2,5-dimethoxyphenyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide 
• 1617522-66-3 5-(2,5-dimethoxyphenyl)-1-methyl-N-(o-tolyl)-1H-pyrazole-3-carboxylic acid amide 

Relevant articles and documents

PYRAZOLO-TRIAZINE AND/OR PYRAZOLO-PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITOR OF CYCLIN DEPENDENT KINASE

The present invention relates to pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[l,5-a]pyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of cell proliferative diseases, inflammatory diseases, immunological diseases, cardiovascular diseases and infectious diseases. Furthermore, the present invention is directed towards pharmaceutical compositions containing at least one of the pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives and/or pharmaceutically acceptable salts thereof.

Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13

Matrix metalloproteases (MMPs) play an important role in cartilage homeostasis under both normal and inflamed disease states and, thus, have become attractive targets for the treatment of arthritic diseases. Herein, we describe the identification of a pot

Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors

A novel class of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as c-Jun-N-terminal kinase (JNK) inhibitors is described. These compounds were synthesized via the condensation of 2-nitrobenzaldehydes and hydroxypyrazoles. The structure-activity relationships (SAR) and kinase selectivity profile of the inhibitors are also discussed. Compound 16 was identified as a potent JNK inhibitor with good cellular potency.