521-12-0

Basic information

• Product Name: Drostanolone propionate
• Synonyms: 17β-Hydroxy-2α-methyl-5α-androstan-3-one propionate;17β-Hydroxy-2α-methylandrostan-3-one propionate;2α-Methyl-17β-hydroxy-5α-androstan-3-one 17-propionate;2α-Methyl-17β-propionoxy-5α-androstan-3-one;2α-Methyl-4,5-dihydrotestosterone propionate;2α-Methylandrostan-17(β)-ol-3-one propionate;2α-Methylandrostan-17β-ol-3-one propionate;2α-Methyldihydrotestosterone propionate
• CAS NO: 521-12-0
• Molecular Formula: C₂₃H₃₆O₃
• Molecular Weight: 360.53
• EINECS: 208-303-1
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Steroid and Hormone;materon
• Mol File: 521-12-0.mol
• Article Data: 0

Chemical Properties

• Melting Point: 114-120°C
• Boiling Point: 432.53°C (rough estimate)
• Flash Point: 190.495 °C
• Appearance: White Solid
• Density: 1.0669 (rough estimate)
• Vapor Pressure: 3.81E-08mmHg at 25°C
• Refractive Index: 1.4700 (estimate)
• Storage Temp.: Controlled Substance, -20?C Freezer
• CAS DataBase Reference: Drostanolone propionate(CAS DataBase Reference)
• NIST Chemistry Reference: Drostanolone propionate(521-12-0)
• EPA Substance Registry System: Drostanolone propionate(521-12-0)

Safety Data

• Hazardous Substances Data: 521-12-0(Hazardous Substances Data)

Usage

Antiestrogenic effects

Dromostanolone Propionate is the propionate salt form of dromostanolone, a synthetic anabolic steroid related to dihydrotestosterone that has antiestrogenic effects. Dromostanolone inhibits the growth of estrogen receptor-presenting breast cancers; its virilizing effects limit its clinical usefulness.Drostanolone propionate is a modified form of drostanolone, where a carboxylic acid ester (propionic acid) has been attached to the 17-beta hydroxyl group.Drostanolone Propionate is a synthetic androgenic anabolic steroid and is approximately 5 times as potent as natural methyltestosterone.

Physiological effect

Like testosterone and other androgenic hormones, dromostanolone binds to the androgen receptor. This causes downstream genetic transcriptional changes. This ultimately causes retention of nitrogen, potassium, and phosphorus; increases protein anabolism; and decreases amino acid catabolism. The antitumour activity of dromostanolone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.Specifically, Masteron is the DHT hormone that has been structurally altered by the addition of a methyl group at the carbon 2 position, This protects the hormone from the metabolic breakdown by the 3-hydroxysteroid dehydrogenase enzyme, which is found in the skeletal muscle.

Description

17b-Hydroxy-2a-methyl-5a-androstan-3-one propionate, also known as drostanolone propionate, is a synthetic anabolic-androgenic steroid. It has similar properties to dihydrotestosterone. It had been used for the treatment of breast cancer in the past. However, it is now mainly used by athletes and bodybuilder as an anabolic steroid. It has two major effects including enhancing the physical/athletic performance (such as endurance and strength) and enhancing physical health (muscle buildup and fat loss). It should be administrated via intramuscular injection instead of oral taking.

Chemical Properties

White Solid

Uses

Drostanolone propionate is the propionate salt form of dromostanolone, a synthetic anabolic steroid related to dihydrotestosterone that has antiestrogenic effects. It is used as an antineoplastic for use in females, for palliation of androgenresponsive recurrent mammary cancer in women who are more than one year but less than five years postmenopausal. Now it is used to help improve athletic performance and muscle gain.

Definition

ChEBI: Drostanolone propionate is a steroid ester and a 3-oxo-5alpha-steroid. It has a role as an antineoplastic agent. It is functionally related to a metholone.

Preparation

Drostanolone propionate is prepared from 9,11-dehydro-17a-methyl-testosterone raw material, reacts with lithium chloride and N-chlorosuccinimide to generate 9a,11-dichloro-17a-methyl- 95 testosterone is further prepared by esterification with propionin.

Therapeutic Function

Cancer chemotherapy

Side effects

As to be expected with all steroids, it's essential that you're aware of all potential side effects of Drostanolone propionate, before you consider a cycle. Side effects of drostanolone propionate include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire. It has no risk of liver damage.

References

https://en.wikipedia.org/wiki/Drostanolone_propionate http://www.chemspider.com/Chemical-Structure.194604.html http://steroid.es/drostanolone.html Chowdhury, M. S., et al. "A comparison of drostanolone propionate (Masteril) and nandrolone decanoate (Deca-durabolin) in the treatment of breast carcinoma. " 2.3(1976):203-206.

InChI:InChI=1/C23H36O3/c1-5-21(25)26-20-9-8-17-16-7-6-15-12-19(24)14(2)13-23(15,4)18(16)10-11-22(17,20)3/h14-18,20H,5-13H2,1-4H3/t14-,15+,16+,17+,18+,20+,22+,23+/m1/s1

Downstream Products

• 1923-17-7 17β-acetoxy-2α-methyl-5α-androstan-3-one 
• 58-19-5 dromostanolone