52225-20-4

Basic information

• Product Name: DL-ALPHA-TOCOPHEROL ACETATE
• Synonyms: 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-,acetate,(2r*(4r*,8r*))-(+-)-2h-1-benzopyran-6-o;3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-,acetate,[2R*(4R*,8R*)]-(+-)-2H-1-Benzopyran-6-ol;acetate,(2r*(4r*,8r*))-(+-)-yl);acetate,[2theta(4theta,8theta)]-(+/-)-yl);ephynal;syntopherolacetate;(+)-A-TOCOPHEROL;EPSILAN-M
• CAS NO: 52225-20-4
• Molecular Formula: C₃₁H₅₂O₃
• Molecular Weight: 472.74
• EINECS: 231-710-0
• Product Categories: Organics
• Mol File: 52225-20-4.mol
• Article Data: 21

Chemical Properties

• Melting Point: -27.5°
• Boiling Point: bp0.01 184°; bp0.025 194°; bp0.3 224°
• Flash Point: 9℃
• Appearance: Clear light yellow to light green/Viscous Liquid
• Density: 0.96 g/mL at 20 °C(lit.)
• Vapor Pressure: 1.42E-09mmHg at 25°C
• Refractive Index: n20/D 1.497
• Storage Temp.: 2-8°C
• CAS DataBase Reference: DL-ALPHA-TOCOPHEROL ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: DL-ALPHA-TOCOPHEROL ACETATE(52225-20-4)
• EPA Substance Registry System: DL-ALPHA-TOCOPHEROL ACETATE(52225-20-4)

Safety Data

• RIDADR: UN 1648 3 / PGII
• WGK Germany: 1
• RTECS: GA8747000
• F: 8-10-23
• Hazardous Substances Data: 52225-20-4(Hazardous Substances Data)

Usage

Chemical Properties

clear light yellow to light green viscous liquid

Uses

Different sources of media describe the Uses of 52225-20-4 differently. You can refer to the following data:
1. As an antioxidant in vegetable oils and shortening.
2. dl-α-Tocopherol Acetate is the racemic analog of α-Tocopherol Acetate (T526155), one of the most bioactive of the naturally occurring forms of Vitamin E. Richest sources are green vegetables, grains, and oils, particularly palm, safflower and sunflower oils.
3. This internal standard is suitable for HPLC or LC-MS/MS Vitamin E testing applications such as quality control testing of Vitamin E fortified foods, dietary supplements, or pharmaceuticals.Tocopheryl Acetate (Vitamin E acetate) may be used as an analytical standard for the determination of the analyte in aquatic organisms, fish feed and pharmaceutical formulations by colorimetric and chromatography techniques, respectively.

General Description

Tocopheryl acetate is a natural form of Vitamin E, used as a fortifying agent and dietary supplement for Vitamin E in food. It is also the main ingredient of skin care products and dermatological preparations. Tocopheryl acetate in combination with α-tocopherol has been used in the therapy of conditions such as sterility, muscular dystrophy, cardiac vascular disorders and anemia.

InChI:InChI=1/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1

Upstream product

• 59-02-9 vitamin E 
• 108-24-7 acetic anhydride 
• 505-32-8 isophytol 
• 36592-62-8 4-acetoxy-2,3,5-trimethylphenol 
• 935-92-2 2,3,5-Trimethyl-1,4-benzoquinone 
• 700-13-0 Trimethylhydroquinone 
• 7479-28-9 2,3,5-trimethyl-1,4-hydroquinone diacetate 
• 64-19-7 acetic acid 
• 78-70-6 3,7-dimethylocta-1,6-dien-3-ol 
• 60018-13-5 3,7-dimethyl-1-octanal 
• 80370-69-0 citronellylmagnesium chloride 
• 728894-66-4 (E,Z)-(all-rac)-3-phytyl-2,5,6-trimethylhydroquinone-1-acetate 
• 696597-97-4 (all-rac)-acetic acid 4-hydroxy-2,3,6-trimethyl-5-[3-(4,8,12-trimethyltridecyl)-but-3-enyl]phenyl ester 
• 286476-98-0 β-springene 

Downstream Products

• 59-02-9 vitamin E 
• 588-46-5 N-(phenylmethyl)acetamide 
• 527-17-3 Duroquinone 

Relevant articles and documents

SYNTHESIS OF CHROMANOL AND 2-METHYL-1,4-NAPHTHOQUINONE DERIVATIVES

The present invention relates to a process for the production of chromanol and 2-methyl-1,4-naphthoquinone derivatives, more specifically to a process for preparing a compound of the general formula (I) or (II) wherein the variables are as defined in the claims and the description.

Vitamin E acetate preparation method (by machine translation)

The invention relates to a technical field of chemical synthesis, in particular relates to a vitamin E acetate preparation method, in order to trimethyl [...][...] as raw materials, innovative in a sulfuric acid and paratoluene sulfonic acid under acidic conditions, using magnesium sulfate as a catalyst, greatly improves the catalytic efficiency; in addition, in concentrated hydrochloric acid and ethyl acetate under the reaction environment, esterification synthetic vitamin E acetate efficiency is higher; and, synthetic route of this invention relates to the reaction of the routine chemical reaction, mild reaction conditions, simple operation, is suitable for industrial. (by machine translation)

Method for preparing d1-alpha tocopheryl acetate

The invention relates to a method for preparing d1-alpha tocopheryl acetate. According to the method, d1-alpha tocopherol or a mixture of d1-alpha tocopherol and d1-alpha tocopheryl acetate serves as a raw material, nitrogen-containing alkaline matter is adopted as a catalyst, acetic acid or acetic anhydride or a mixture of acetic acid and acetic anhydride serves as an acylating agent, and a d1-alpha tocopheryl acetate product is obtained through an esterification reaction. The preparation method is simple as a whole, operability is good, the yield is high, product quality is good, and besides risks in the aspects of the environment and safety are small.