52311-59-8

Basic information

• Product Name: 4-Chloro-2-nitrobenzyl bromide
• Synonyms: 4-Chloro-2-nitrobenzyl bromide;2-Nitro-4-chlorobenzyl bromide
• CAS NO: 52311-59-8
• Molecular Formula: C₇H₅BrClNO₂
• Molecular Weight: 250.4771
• Mol File: 52311-59-8.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-Chloro-2-nitrobenzyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-2-nitrobenzyl bromide(52311-59-8)
• EPA Substance Registry System: 4-Chloro-2-nitrobenzyl bromide(52311-59-8)

Safety Data

• Hazardous Substances Data: 52311-59-8(Hazardous Substances Data)

Usage

General Description

4-Chloro-2-nitrobenzyl bromide is a chemical compound with the molecular formula C7H5ClBrNO2. It is a pale yellow solid that is used as a reagent in organic synthesis. 4-Chloro-2-nitrobenzyl bromide is often employed in the production of pharmaceuticals, agrochemicals, and dyes. It is a versatile intermediate that can undergo various reactions, including nucleophilic substitution and reduction, to yield a wide range of useful compounds. 4-Chloro-2-nitrobenzyl bromide is considered to be a hazardous material and should be handled with care and proper safety precautions.

Upstream product

• 89-59-8 4-chloro-2-nitrotoluene 
• 5551-11-1 4-Chloro-2-nitrobenzaldehyde 
• 6280-88-2 4-chloro-2-nitro-benzoic acid 
• 22996-18-5 (4-chloro-2-nitrophenyl)methanol 

Downstream Products

• 918342-97-9 N-(3,5-Dichloropyridin-4-yl)-[7-benzyloxy-1-(4-chloro-2-nitrobenzyl)-indol-3-yl]glyoxylic acid amide 
• 1269005-12-0 4-chloro-1-(2-methylbenzyl)-2-nitrobenzene 
• 1269005-14-2 5-chloro-2-(2-methylbenzyl)aniline 
• 1422192-29-7 8-chloro-2-(phenylsulfonyl)-1,2,3,4,5,6-hexahydroazepino[4,3-b]indole 
• 1422193-04-1 3-chloro-6-((1-(phenylsulfonyl)piperidin-3-ylidene)methyl)aniline 
• 49641-17-0 trans-4,4'-dichloro-2,2'-dinitrostilbene 
• 1333547-33-3 4-chloro-2-nitrobenzyltriphenylphosphonium bromide 
• 1148-57-8 4-chloro-2-nitrobenzylsulfonylacetic acid 
• 1330633-76-5 (E)-2',4',6'-trimethoxystyryl-4-chloro-2-aminobenzylsulfone 
• 1330634-14-4 (E)-2',4',6'-trimethoxystyryl-4-chloro-2-nitrobenzylsulfone 
• 1668-78-6 4-chloro-2-nitrobenzylthioacetic acid 
• 1290617-56-9 tert-butyl 4-chloro-N-(diphenylmethylidene)-2-nitro-L-phenylalaninate 
• 922711-92-0 C₁₀H₈ClN₃O₂ 
• 56433-05-7 4-Chlor-2-nitro-phenylalanin 

Relevant articles and documents

3-OXAZOLINONE COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF

The present invention relates to a novel 3-indazolinone compound that regulates or inhibits the activity of indoleamine 2,3-dioxygenase (IDO), the method for the preparation thereof and the use thereof in medicine. In particular, the present invention relates to a compound represented by the general formula (I) and a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the compound or a pharmaceutically acceptable salt thereof, a method for treating or preventing IDO-mediated diseases, especially tumors, by use of the compound or a pharmaceutically acceptable salt thereof, and a method for preparing the compound or a pharmaceutically acceptable salt thereof. The present invention further relates to use of the compound or a pharmaceutically acceptable salt thereof or a composition comprising the compound or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for treating or preventing IDO-mediated diseases, especially tumors.Wherein the substituents of the general formula (I) are defined the same as that in the specification.

Access to Chiral Seven-Member Cyclic Amines via Rh-Catalyzed Asymmetric Hydrogenation

A highly efficient asymmetric hydrogenation of azepine/oxazepine-type seven-member cyclic imine hydrochlorides was successfully developed using Rh/bisphosphine-thiourea ligand ZhaoPhos, affording various chiral seven-member cyclic amines with full conversions, high yields, and excellent enantioselectivities (up to 96% yield, >99% ee). Additionally, this asymmetric hydrogenation can proceed well on gram scale with excellent ee value. Moreover, control experimental results displayed that the anion-bonding interaction between the chloride ion of the substrate and thiourea motif of the ZhaoPhos played an important role to obtain excellent enantioselectivity.

AMINO SUBSTITUTED DIARYL [A, D] CYCLOHEPTENE ANALOGS AS MUSCARINIC AGONISTS AND METHODS OF TREATMENT OF NEUROPSYCHIATRIC DISORDERS

Disclosed herein are analogs of clozapine and pharmaceutically acceptable salts, esters, amides, or prodrugs thereof; methods of synthesizing the analogs; and methods of using the analogs for treating neuorpsychiatric disorders. In some embodiments, the analogs are amino substituted diaryl[a,d]cycloheptenes.