5234-86-6

Basic information

• Product Name: 1,3,4,6,7,11b-Hexahydro-2H-pyrazino[2,1-a]isoquinoline
• Synonyms: 1,3,4,6,7,11b-Hexahydro-2H-pyrazino[2,1-a]isoquinoline;Azaquinzole;2,3,4,6,7,11B-HEXAHYDRO-1H-PYRAZINO[2,1-A]ISOQUINOLINE;2H-Pyrazino[2,1-a]isoquinoline, 1,3,4,6,7,11bhexahydro-
• CAS NO: 5234-86-6
• Molecular Formula: C12H18Cl2N2
• Molecular Weight: 261.2
• Mol File: 5234-86-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 319.9°C at 760 mmHg
• Flash Point: 150.4°C
• Appearance: /
• Density: 1.13g/cm³
• Vapor Pressure: 0.00033mmHg at 25°C
• Refractive Index: 1.617
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 1,3,4,6,7,11b-Hexahydro-2H-pyrazino[2,1-a]isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,4,6,7,11b-Hexahydro-2H-pyrazino[2,1-a]isoquinoline(5234-86-6)
• EPA Substance Registry System: 1,3,4,6,7,11b-Hexahydro-2H-pyrazino[2,1-a]isoquinoline(5234-86-6)

Safety Data

• Hazardous Substances Data: 5234-86-6(Hazardous Substances Data)

Usage

Originator

Azaquinzole,Onbio Inc.

Manufacturing Process

2 Methods of producing of 1,2,3,6,7,11b-hexahydro-4H-pyrazino-[2,1- a]isoquinoline: 1). 214.0 g diethyl ester of oxalic acid are mixed with a solution of 238.0 g 1- aminomethyl-1,2,3,4-tetrahydroisoquinoline in 200 ml alcohol are boiled for 7 h. After cooling, the obtained crystals of 1,2,3,6,7,11b-hexahydro-4Hpyrazino[ 2,1-a]isoquinoline-3,4-dione are vacuum-filtered and washed with acetone and dried, melting point 220°C. Yield: 240.0 g. 55.0 g lithium aluminum hydride are dissolved in 650 ml absolute tetrahydrofuran and mixed dropwise with a suspension of 120.0 g 1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline-3,4-dione in 300 ml absolute tetrahydrofuran. After 7 h of boiling, the residual hydride is decomposed by the addition of water, and the reaction solution is worked up. The obtained 1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline is distilled in vacuum, boiling point 98°-100°C/0.01 mm. Yield: 86.0 g. 2). 16.2 g 1-aminomethyl-1,2,3,4-tetrahydroisoquinoline and 18.7 g ethylene dibromide are boiled for 4 h in n-butanol, with the addition of 13.8 g potassium carbonate. After the solvent is evaporated, the residue is treated with water, mixed with sodium hydroxide solution, and shaken out with chloroform. The chloroform solution is dried, concentrated by evaporation, and the resulting 1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline is distilled at 98°-100°C/0.01 mm. The yield amounts to 7.5 g.

Therapeutic Function

CNS depressant

InChI:InChI=1/C12H16N2/c1-2-4-11-10(3-1)5-7-14-8-6-13-9-12(11)14/h1-4,12-13H,5-9H2

Upstream product

• 55268-74-1 2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one 
• 61196-37-0 2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one 

Downstream Products

• 5315-01-5 phenyl-(3,4,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-2(11bH)-yl)methanone 

Relevant articles and documents

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