52363-40-3Relevant articles and documents
Intramolecular Diels-Alder chemistry of 4-vinylimidazoles
He, Yong,Krishnamoorthy, Pasupathy,Lima, Heather M.,Chen, Yingzhong,Wu, Haiyan,Sivappa, Rasapalli,Dias, H. V. Rasika,Lovely, Carl J.
scheme or table, p. 2685 - 2701 (2011/05/08)
An investigation of 4-vinylimidazoles as diene components in the intramolecular Diels-Alder reaction is described. In the course of these studies several parameters affecting the cycloaddition were evaluated including the nature of the imidazole protecting group, the type of dienophile and the linking group. These investigations established that amino linkers were generally more effective than either ethers or esters. In most cases, the cycloadditions were highly stereoselective, resulting in the formation of products derived from an anti transition state. The polysubstituted tetrahydrobenzimidazole core of the pyrrole-imidazole alkaloid ageliferin can be constructed through the use of pseudo dimeric 4-vinylimidazoles.
Efficient preparation of urocanic acid derivatives from histidine
Lovely, Carl J.,Sivappa, Rasapalli,Mukherjee, Sabuj,Doundoulakis, Thomas,Lima, Heather M.,Yousufuddin, Muhammed
scheme or table, p. 1353 - 1358 (2010/10/20)
Urocanic acid derivatives have served as useful starting materials in several total synthesis endeavors in our lab. This paper describes a convenient, large-scale synthesis of several derivatives of urocanic acid via the net elimination of ammonia from hi
N-benzyl imidazole derivatives and their use as aldosterone synthase inhibitors
-
Page/Page column 6-7, (2009/09/26)
The invention relates to the use of a N-benzyl 5-substituted imidazole derivative having the general formula I wherein R is (C1-3)alkyl, (C1-3)alkyloxy, halogen, nitro or cyano; R1 is (C1-6)alkyl, optionally substituted with OH, (C1-3)alkyloxy, (C1-3)alkylcarbonyloxy, (C1-3)alkyloxycarbonyl or halogen, or (C1-3)alkyloxycarbonyl; or R1 is phenyl, optionally substituted with 1-3 substituents independently selected from (C1-3)alkyl, (C1-3)alkyloxy, hydroxylmethyl and halogen; or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for the treatment of a disorder or disease in a subject mediated by aldosterone synthase or responsive to inhibition of aldosterone synthase.
