5241-59-8

Basic information

• Product Name: H-D-PHE-NH2
• Synonyms: H-D-PHE-NH2;D-PHENYLALANINE AMIDE;D-PHENYLALANINE-NH2;(2R)-2-AMINO-3-PHENYLPROPIONYL AMIDE;BenzenepropanaMide, a-aMino-, (R)-;(R)-α-AMino-hydrocinnaMaMide;(αR)-α-AMino-benzenepropanaMide;D-PhenylalaninaMide
• CAS NO: 5241-59-8
• Molecular Formula: C₉H₁₂N₂O
• Molecular Weight: 164.2
• Product Categories: Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Chiral Reagents;Aromatics
• Mol File: 5241-59-8.mol
• Article Data: 21

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• CAS DataBase Reference: H-D-PHE-NH2(CAS DataBase Reference)
• NIST Chemistry Reference: H-D-PHE-NH2(5241-59-8)
• EPA Substance Registry System: H-D-PHE-NH2(5241-59-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 5241-59-8(Hazardous Substances Data)

Usage

Chemical Properties

Yellowish Solid

Upstream product

• 108321-83-1 phenylalanine amide hydrochloride 
• 2448-45-5 Cbz-D-Phe 
• 673-06-3 D-(R)-phenylalanine 
• 17193-31-6 (R,S)-2-amino-3-phenylpropionamide 
• 55379-75-4 2-amino-3-phenylpropanenitrile 
• 15028-44-1 DL-phenylalanine methyl ester 
• 5241-56-5 (R)-benzyl (1-amino-1-oxo-3-phenylpropan-2-yl)carbamate 
• 155385-83-4 (-)-1-<(1-cyano-2-phenylethyl)amino>-2R-methyl-5R-(1-methylethenyl)cyclohexane-1R,3R-dicarbonitrile 
• 13033-84-6 D-phenylalanine methyl ester hydrochloride 
• 21685-51-8 D-phenylalanine methyl ester 
• 5241-58-7 L-Phenylalanine amide 
• 129095-62-1 (R)-tert-butyl (1-amino-1-oxo-3-phenylpropan-2-yl)carbamate 
• 18942-49-9 Boc-D-Phe-OH 
• 13250-12-9 (R)-sec-butylamine 

Downstream Products

• 74822-65-4 (R)-(+)-1,2-diamino-3-phenylpropane dihydrochloride 
• 56672-76-5 1-hippuroyl-L-proline 
• 500767-16-8 (2R,5S,6S)-3-aza-2-benzyl-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenylheptanoyl amide 
• 86961-06-0 malonyl-D-phenylalanine amide 
• 63-91-2 L-phenylalanine 
• 129095-62-1 (R)-tert-butyl (1-amino-1-oxo-3-phenylpropan-2-yl)carbamate 
• 1350980-62-9 N-(1-oxyl-4'-demethyl-4-deoxypodophyllic)-D-phenylalanine amide 
• 500767-30-6 (2R,5S,6S)-3-aza-2-benzyl-3-(benzyloxycarbonyl)-6-[[(tert-butyloxycarbonyl)-L-valinyl]amino]-5-hydroxy-7-phenylheptanoyl amide 

Relevant articles and documents

Hybrid catalysis of 8-quinolinecarboxaldehyde and br?nsted acid for efficient racemization of α-amino amides and its application in chemoenzymatic dynamic kinetic resolution

The combination of 8-quinolinecarboxaldehyde and benzoic acid proved to be an effective catalyst system for the racemization of N-unprotected α-aryl- or α-alkyl-substituted α-amino amides. Application of this system to chemoenzymatic dynamic kinetic resolution provided an efficient access to enantiomerically pure N-acetyl-α-amino amides in good to high yields.

Synthetic method for chiral alpha-aminoamide compounds

The invention provides a synthetic method for chiral alpha-aminoamide compounds, belongs to the technical field of organic synthetic methodology, and concretely relates to a synthetic method for chiral alpha-aminoamide compounds, wherein the method has a simple process, low costs and good economy. The method comprises the following steps: 1, performing ammonolysis: adding substituted chiral alpha-aminocarboxylate hydrochloride into concentrated ammonia water, performing stirring for 4-12h under a room temperature, wherein each 1mmol substituted chiral alpha-aminocarboxylate hydrochloride is corresponding to 2-8mL the concentrated ammonia water; 2, after a reaction is finished, performing distillation for removing ammonia water after the reaction to obtain crude products chiral alpha-aminoamide compounds; and 3, performing filtration on the obtained crude products chiral alpha-aminoamide compounds by adopting a manner of adding a solvent or performing purification on the obtained crude products chiral alpha-aminoamide compounds through a manner of column chromatography which uses ammonia water as a mobile phase to obtain the products chiral alpha-aminoamide compounds. Compared with the prior art, a large number of an ammonia gas for ammonolysis is not needed in the method, the process and post-treatment are simple, costs are low and reaction time is short.

2-(N-Benzyl-N-phenylsulfonamido)alkyl amide derivatives as γ-secretase inhibitors

A series of (N-benzyl-N-phenylsulfonamido)alkyl amides were developed from classic and parallel synthesis strategies. Compounds with good in vitro and in vivo γ-secretase activity were identified and described.