52468-48-1

Basic information

• Product Name: butyl 2-chlorobenzoate
• Synonyms: Benzoic acid, 2-chloro, butyl ester
• CAS NO: 52468-48-1
• Molecular Formula: C₁₁H₁₃ClO₂
• Molecular Weight: 212.6727
• Mol File: 52468-48-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 278.9°C at 760 mmHg
• Flash Point: 129.8°C
• Density: 1.126g/cm³
• Vapor Pressure: 0.00414mmHg at 25°C
• Refractive Index: 1.513
• CAS DataBase Reference: butyl 2-chlorobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: butyl 2-chlorobenzoate(52468-48-1)
• EPA Substance Registry System: butyl 2-chlorobenzoate(52468-48-1)

Safety Data

• Hazardous Substances Data: 52468-48-1(Hazardous Substances Data)

Upstream product

• 58274-24-1 1-Chloro-2-dibutoxymethyl-benzene 
• 873-32-5 2-Chlorobenzonitrile 
• 71-36-3 butan-1-ol 
• 201230-82-2 carbon monoxide 
• 615-41-8 2-iodochlorobenzene 
• 17849-38-6 2-Chlorobenzyl alcohol 
• 609-66-5 2-chlorobenzamide 
• 2856-63-5 2-Chlorophenylacetonitrile 
• 37170-50-6 di(methyl)tert-butyl(n-butoxy)silane 
• 89-98-5 2-chloro-benzaldehyde 
• 694-80-4 2-bromo-1-chlorobenzene 

Downstream Products

• 17261-28-8 ortho-diphenylphosphinobenzoic acid 

Relevant articles and documents

Mechanistic insight into the synergistic Cu/Pd-catalyzed carbonylation of aryl iodides using alcohols and dioxygen as the carbonyl source

Pd-catalyzed carbonylation, as an efficient synthetic approach to the installation of carbonyl groups in organic compounds, has been one of the most important research fields in the past decade. Although elegant reactions that allow highly selective carbonylations have been developed, straightforward routes with improved reaction activity and broader substrate scope remain long-term challenges for new practical applications. Here, we show a new type of synergistic Cu/Pd-catalyzed carbonylation reaction using alcohols and dioxgen as the carbonyl sources. A broad range of aryl iodides and alcohols are compatible with this protocol. The reaction is concise and practical due to the ready availability of the starting materials and the scalability of the reaction. In addition, the reaction affords lactones and lactams in an intermolecular fashion. Moreover, DFT calculations have been performed to study the detailed mechanisms. [Figure not available: see fulltext.]

Cross-Dehydrogenating Coupling of Aldehydes with Amines/R-OTBS Ethers by Visible-Light Photoredox Catalysis: Synthesis of Amides, Esters, and Ureas

A straightforward synthesis of amides, ureas, and esters is reported by visible-light cross-dehydrogenating coupling (CDC) of aldehydes (or amine carbaldehydes) and amines/R-OTBS ethers by photoredox catalysis. The reaction is found to be general and high yielding. A plausible mechanistic pathway has been proposed for these transformations and is supported by appropriate controlled experiments.

Combined catalytic system of scandium triflate and boronic ester for amide bond cleavage

We have found that the combination of scandium with boronic ester enables the cleavage of amide bonds. Primary amides were converted to the corresponding esters in the presence of catalytic amounts of scandium triflate and boronic ester under mild and neutral conditions. This unique catalytic system can be applied to the deprotection of acetylaniline derivatives. In addition, control NMR experiments were carried out to examine the effect of the boronic esters. Copyright