52486-70-1

Basic information

• Product Name: Acetic acid, aMinocyano-, Methyl ester
• Synonyms: Acetic acid, aMinocyano-, Methyl ester;Methyl 2-amino-2-cyanoacetate
• CAS NO: 52486-70-1
• Molecular Formula: C4H6N2O2
• Molecular Weight: 114.10264
• Mol File: 52486-70-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 191.5±25.0 °C(Predicted)
• Appearance: /
• Density: 1.194±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 2.66±0.50(Predicted)
• CAS DataBase Reference: Acetic acid, aMinocyano-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, aMinocyano-, Methyl ester(52486-70-1)
• EPA Substance Registry System: Acetic acid, aMinocyano-, Methyl ester(52486-70-1)

Safety Data

• Hazardous Substances Data: 52486-70-1(Hazardous Substances Data)

Upstream product

• 61295-92-9 methyl 2-cyano-2-hydroxyiminoacetate 

Downstream Products

• 1004-75-7 2,5,6-triamino-4-hydroxypyrimidine 
• 38716-32-4 5-amino-2-(tri-O-benzoyl-β-D-ribofuranosyl)-1(3)H-imidazole-4-carboxylic acid methyl ester 

Relevant articles and documents

Synthesis process, intermediate and pharmaceutical process of 2, 4, 5-triamino-6-hydroxypyrimidine

The invention discloses a synthesis process of 2, 4, 5-triamino-6-hydroxypyrimidine, which comprises the following steps: 1) carrying out pressurized catalytic hydrogenation reaction on liquid 2-nitroso and 2-methyl cyanoacetate/ethyl cyanoacetate to generate 2-amino and 2-cyanoacetic acid methyl ester/ethyl ester; (2) carrying out cyclization reaction on the 2-amino, 2-methyl cyanoacetate/ethyl cyanoacetate and free guanidine to generate 2, 4, 5-triamino-6-hydroxypyrimidine; wherein the liquid 2-nitroso and 2-methyl cyanoacetate/ethyl cyanoacetate in the step 1) are generated by carrying out nitrosation reaction on methyl cyanoacetate/ethyl cyanoacetate and sodium nitrite. The invention also discloses intermediates 2-nitroso and 2-methyl cyanoacetate in the synthesis process, a synthesis process of the intermediates, and a pharmaceutical process taking the 2, 4, 5-triamino-6-hydroxypyrimidine as an intermediate. According to the present invention, the liquid new compounds such as 2-nitroso and 2-methyl cyanoacetate/ethyl cyanoacetate are subjected to the catalytic hydrogenation reaction, such that the problems of large water consumption and large wastewater yield in the 2, 4, 5-triamino-6-hydroxypyrimidine synthesis process can be solved, and the great economic significance and the great environmental protection significance are provided.

Enchainements heteroatomiques et leurs produits de cyclisation. VI. Nouvelle synthese de cephemes: acetyl-3 methyl-7 phtalimido-7 oxo-8 thia-5 aza-1 bycyclooctenes-2 diastereomers

The total synthesis of two diastereomeric cephems is described with three original steps in excellent yields: construction of the 1,3-thiazine ring via a (4+2) cycloaddition reaction, regioselective hydrogenation of the carbon-nitrogen double bond, and la