5255-33-4

Basic information

• Product Name: 4-METHYL-5-THIAZOLEACETIC ACID
• Synonyms: 4-METHYL-5-THIAZOLEACETIC ACID;4-methyl-5-thiazoleaceticaci;4-methylthiazol-5-acetic acid;2-(4-methyl-1,3-thiazol-5-yl)acetic acid;2-(4-methyl-1,3-thiazol-5-yl)ethanoic acid;2-(4-methylthiazol-5-yl)acetic acid;2-(4-methyl-5-thiazolyl)acetic acid;2-(4-Methylthiazol-5-yl)
• CAS NO: 5255-33-4
• Molecular Formula: C₆H₇NO₂S
• Molecular Weight: 157.19
• EINECS: 226-056-8
• Mol File: 5255-33-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 315.1 °C at 760 mmHg
• Flash Point: 144.4 °C
• Appearance: /
• Density: 1.356 g/cm³
• Vapor Pressure: 0.000189mmHg at 25°C
• Refractive Index: 1.582
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-METHYL-5-THIAZOLEACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-5-THIAZOLEACETIC ACID(5255-33-4)
• EPA Substance Registry System: 4-METHYL-5-THIAZOLEACETIC ACID(5255-33-4)

Safety Data

• Hazardous Substances Data: 5255-33-4(Hazardous Substances Data)

Usage

General Description

4-Methyl-5-thiazoleacetic acid is a chemical compound with the molecular formula C6H7NO2S. It is classified as a thiazole derivative, which is a heterocyclic compound containing both sulfur and nitrogen atoms. 4-METHYL-5-THIAZOLEACETIC ACID is commonly used in the pharmaceutical and agricultural industry as a building block for the synthesis of various drugs and agrochemicals. Its unique chemical structure and functional groups make it a versatile intermediate for the production of organic compounds. 4-Methyl-5-thiazoleacetic acid has potential applications in the development of new medications and crop protection products due to its diverse reactivity and pharmacological properties.

InChI:InChI=1/C6H7NO2S/c1-4-5(2-6(8)9)10-3-7-4/h3H,2H2,1H3,(H,8,9)

Upstream product

• 406727-23-9 (4-methyl-thiazol-5-yl)-acetic acid ethyl ester 
• 137-00-8 5-hydroxyethyl-4-methylthiazole 
• 59-43-8 vitamin B₁ 

Downstream Products

• 82294-70-0 4-methyl-1,3-thiazole-5-carbaldehyde 

Relevant articles and documents

Autocatalytic Oxidation of Thiamine Hydrochloride (Vitamin B1) by Permanganate in Aqueous Sulfuric Acid Medium: A Kinetic and Mechanistic Study

The reaction kinetics of autocatalytic oxidation of thiamine hydrochloride (vitamin B1) by the permanganate ion in aqueous sulfuric acid medium has been investigated spectrophotometrically under the pseudo-first-order condition at 25°C. The observed stoichiometry is 6:5 in terms of the mole ratio of permanganate ions and thiamine hydrochloride. Formation of products was confirmed by UV-vis, IR, GC-MS, and NMR spectral data. Usually in the permanganate oxidation-reduction reactions, one of the products, Mn2+ autocatalyzes the reaction, but in the present investigation the autocatalytic effect is due to the (4-methyl-thiazol-5-yl) acetic acid, a product formed from the oxidation of vitamin B1, which is a rare case. The added Mn2+ does not have any significant effect on the rate of reaction. The reaction is first order with respect to both permanganate and thiamine hydrochloride concentrations. An increase in the sulfuric acid concentration decreases the rate of reaction. A composite scheme and rate laws were proposed. The activation parameters with respect to the slow step and reaction constants involved in the mechanism were determined and discussed.