526-18-1

Basic information

• Product Name: 2-Hydroxy-N-(4-hydroxyphenyl)-benzamide
• Synonyms: LOIRD;2-hydroxy-n-(4-hydroxyphenyl)-benzamide;OSALMID;N-SALICYLOYL-P-AMINOPHENOL;N-(4-HYDROXYPHENYL)SALICYLAMIDE;2-hydroxy-n-(4-hydroxyphenyl)-benzamid;4’-hydroxy-salicylanilid;4’-hydroxysalicylanilide
• CAS NO: 526-18-1
• Molecular Formula: C₁₃H₁₁NO₃
• Molecular Weight: 229.23
• EINECS: 208-385-9
• Mol File: 526-18-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 179°
• Boiling Point: 371.13°C (rough estimate)
• Flash Point: 165.9 °C
• Appearance: White crystal
• Density: 1.2084 (rough estimate)
• Vapor Pressure: 2.12E-05mmHg at 25°C
• Refractive Index: 1.5500 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.40±0.30(Predicted)
• Water Solubility: 916mg/L at 25℃
• CAS DataBase Reference: 2-Hydroxy-N-(4-hydroxyphenyl)-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-N-(4-hydroxyphenyl)-benzamide(526-18-1)
• EPA Substance Registry System: 2-Hydroxy-N-(4-hydroxyphenyl)-benzamide(526-18-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38-42/43
• Safety Statements: 26-36/37
• Hazardous Substances Data: 526-18-1(Hazardous Substances Data)

Usage

Biochem/physiol Actions

Osalmid is a potent inhibitor of ribonucleotide reductase small subunit M2 (RRM2) that potently inhibits HBV DNA and cccDNA synthesis in HepG2.2.15 cells. Osalmid inhibits RR (ribonucleotide reductase) activity in vivo, and exhibits synergistic effect with lamivudine on inactivation mutant HBV strain. Osalmid is a biliation activator (choleretic agent), but a mechanism of this activity remains unknown.

InChI:InChI=1/C13H11NO3/c15-10-7-5-9(6-8-10)14-13(17)11-3-1-2-4-12(11)16/h1-8,15-16H,(H,14,17)

Upstream product

• 123-30-8 4-amino-phenol 
• 118-55-8 phenyl Salicylate 
• 69-72-7 salicylic acid 
• 65-45-2 salicylamide 
• 19065-81-7 2-acetoxy-benzoic acid-(4-hydroxy-anilide) 

Downstream Products

• 52942-41-3 3-(4-hydroxy-phenyl)-benzo[e][1,3]oxazine-2,4-dione 
• 69319-30-8 2-methyl-3-(p-vinyloxyphenyl)-2,3-dihydro-4H-1,3-benzoxazin-4-one 
• 86269-47-8 2-vinyloxybenzoic acid p-hydroxyanilide 
• 86269-44-5 2-hydroxybenzoic acid p-vinyloxyanilide 
• 20978-99-8 2-methyl-3-(p-ethoxyphenyl)-2,3-dihydro-4H-1,3-benzoxazin-4-one 
• 36957-34-3 1-acetoxy-4-(2-acetoxy-benzoylamino)-benzene 

Relevant articles and documents

A pharmaceutical intermediate liu Anfen N-P-hydroxy phenyl salicylic amide synthesis method (by machine translation)

A pharmaceutical intermediate liu Anfen N-P-hydroxy phenyl salicylic amide synthesis method, comprising the following steps: in the reaction container to aminophenol 0.07mol, 2-hydroxy-benzamide 0.074 the [...] 0.076mol, ethyl acetate the 70 [...] 80 ml, control the stirring speed in the 110 [...] 150rpm, slowly adding stannous chloride 0.031mol, darkening solution, after adding slowly increasing the temperature to 160 - - 170°C, reaction 5 the [...] 6h, vacuum distillation, boil off some ethyl acetate, reducing the temperature of the solution to 35 - - 38°C, the reactants are poured into a 500 ml in sodium bisulfite solution, layering, layer plus molecular sieve decolourizations, filtering, the filtrate by adding oxalic acid solution, adjusting the pH to 3 the [...] 4, separating solid, re-crystallization in the ethylenediamine solution, the white solid obtained N-P-hydroxy phenyl salicylic amide; wherein the step of pressure at the pressure of the distillation the 1.9 [...] 2.1kPa. (by machine translation)