526-35-2 Usage
Originator
Aloxidone ,ZYF Pharm Chemical
Manufacturing Process
A mixture of 11.4 parts of 5-methyloxazolidine-2,4-dione and 15 parts
anhydrous potassium carbonate in 150 parts of dry acetone is stirred for 0.5
hour. 15 parts of allyl bromide are then added and the mixture boiled under
reflux with stirring for 4 hours. After cooling and filtering, the solvent and any
unchanged allyl bromide are removed by distillation. The residue is extracted
with ether end the extract washed with saturated aqueous sodium bicarbonate
until the subsequent water-washings are either neutral or just alkaline to
litmus paper. The solvent is then distilled and the residue fractionated when 3-
allyl-5-methyloxazolidine-2,4-dione is obtained in 65% yield as a colorless oil,
BP: 88°-90°C/1.8 mm, nd20 = 1.4710.
The dry sodium salt of 5-methyloxazolidine-2,4-dione, obtained from 4.6 parts
of sodium, 100 parts of ethanol, 12 parts of urea and 23.6 parts of ethyl
lactate, is suspended in 100 parts of dry benzene and 30.25 parts of allyl
bromide are added. The mixture is boiled under reflux for 20 hours and the
benzene decanted or filtered from any solid. The solution is washed with saturated aqueous sodium bicarbonate until the subsequent water-washings
are neutral or just alkaline to litmus paper. The dried benzene solution is then
distilled to remove solvent and the residue fractionated, when 3-allyl-5-
methylosazolidine-2,4-dione is obtained in 27% yield as a colorless oil, BP:
89°-90°C/1 mm, nd20 = 1.4712.
The dry sodium salt of 5-methyloxazolidine-2,4-dione obtained as above is
mixed with 100 parts of dry dioxane and 31.25 parts of allyl bromide are
added. After boiling under reflex for 24 hours, decanting the solution and
distilling off the dioxane under reduced pressure, the residue is dissolved in
ether and the ethereal extract mashed with aqueous sodium bicarbonate as
above. Fractionation of the residue after removing the olvent furnishes 3-allyl-
5-methyloxazolidine-2,4-dione in 48.5% yield as a colorless oil; BP: 94°-
95°C/11.75 mm; nd20 = 1.4710.
Check Digit Verification of cas no
The CAS Registry Mumber 526-35-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,2 and 6 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 526-35:
(5*5)+(4*2)+(3*6)+(2*3)+(1*5)=62
62 % 10 = 2
So 526-35-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H9NO3/c1-3-4-8-6(9)5(2)11-7(8)10/h3,5H,1,4H2,2H3
526-35-2Relevant articles and documents
A safe and mild synthesis of organic carbonates from alkyl halides and tetrabutylammonium alkyl carbonates
Verdecchia, Mirella,Feroci, Marta,Palombi, Laura,Rossi, Leucio
, p. 8287 - 8289 (2007/10/03)
A safe and mild procedure for the synthesis of mixed organic carbonates is described. Reaction of commercially available tetrabutylammonium methoxide and ethoxide with carbon dioxide yields the corresponding methyl and ethyl tetrabutylammonium carbonates (TBAMC and TBAEC). The reactions of these new compounds with several different alkyl halides give methyl and ethyl carbonates in high yields. The use of classic toxic and harmful chemicals such as phosgene and carbon monoxide is avoided.
Activation of carbon dioxide by electrogenerated superoxide ion: A new carboxylating reagent
Casadei, Maria Antonietta,Cesa, Stefania,Micheletti Moracci, Franco,Inesi, Achille,Feroci, Marta
, p. 380 - 383 (2007/10/07)
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DIASTEREOSELECTIVE SYNTHESIS OF TRANS-4,5-DISUBSTITUTED OXAZOLIDIN-2-ONES AND VICINAL AMINO ALCOHOLS THROUGH ALKYLATION OF N-ACYLIMINIUM ION INTERMEDIATES
Kano, Shinzo,Yuasa, Yoko,Shibuya, Shiroshi
, p. 373 - 376 (2007/10/02)
Treatment of 5-substituted 4-ethoxyoxazolidin-2-ones (10a-f, 13a,b) with allyltrimethylsilane in the presence of titanium tetrachloride gave the corresponding trans-4,5-disubstituted oxazolidin-2-ones (14a-f, 16a,b), respectively, with high diastereoselectivity.Methallylation of 13a,b with methallyltrimethylsilane yielded 16c,d, respectively.Ring cleavage of 14a-f afforded the corresponding threo vicinal amino alcohols 17a-f, respectively.