5267-49-2

Basic information

• Product Name: (4-METHYLPHENYL)(PHENYL)METHANAMINE HYDROCHLORIDE
• CAS NO: 5267-49-2
• Molecular Weight: 233.73654
• Mol File: 5267-49-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (4-METHYLPHENYL)(PHENYL)METHANAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-METHYLPHENYL)(PHENYL)METHANAMINE HYDROCHLORIDE(5267-49-2)
• EPA Substance Registry System: (4-METHYLPHENYL)(PHENYL)METHANAMINE HYDROCHLORIDE(5267-49-2)

Safety Data

• Hazardous Substances Data: 5267-49-2(Hazardous Substances Data)

Usage

General Description

(4-Methylphenyl)(phenyl)methanamine hydrochloride is a chemical compound with the molecular formula C14H15N·HCl. It is a hydrochloride salt of (4-methylphenyl)(phenyl)methanamine, which is an organic compound with a phenyl and a methyl group attached to an amine functional group. (4-METHYLPHENYL)(PHENYL)METHANAMINE HYDROCHLORIDE is commonly used in chemical research and pharmaceutical manufacturing. It is important to handle this compound with care and follow appropriate safety protocols, as it may pose health risks if mishandled.

Upstream product

• 55095-21-1 phenyl-p-tolylmethylamine 
• 100-46-9 benzylamine 
• 108-86-1 bromobenzene 
• 56542-88-2 N-(4-methylbenzyl)-1,1-diphenylmethanimine 
• 106-38-7 para-bromotoluene 
• 7699-79-8 benzhydrylidene-benzyl-amine 
• 134-84-9 4-Methylbenzophenone 
• 180399-94-4 N-(Diethoxyphosphoryl)benzylideneimine 
• 1069136-40-8 N-(4-methylphenylmethyl)xanthone imine 
• 108-90-7 chlorobenzene 
• 6229-07-8 N-benzylxanthone imine 
• 106-43-4 para-chlorotoluene 

Downstream Products

• 1351866-39-1 (R)-(+)-N-[(4-methylphenyl)(phenyl)methyl]acetamide 
• 1246754-95-9 (S)-(-)-N-[(4-methylphenyl)(phenyl)methyl]acetamide 

Relevant articles and documents

Synthesis of diarylmethylamines via palladium-catalyzed regioselective arylation of 1,1,3-triaryl-2-azaallyl anions

Diarylmethylamines are of great interest due to their prevalence in pharmaceutical chemistry. As a result, new methods for their synthesis are in demand. Herein, we report a versatile protocol for the synthesis of diarylmethylamine derivatives involving palladium-catalyzed arylation of in situ generated 2-azaallyl anion intermediates. The 2-azaallyl anions are generated by reversible deprotonation of readily available aldimine and ketimine precursors. Importantly, the arylated aldimine and ketimine products do not undergo isomerization under the reaction conditions. Scale-up of the arylation and hydrolysis of the resulting products to furnish diarylmethylamines were also successfully performed. This journal is the Partner Organisations 2014.

Palladium-catalyzed benzylic arylation of N-benzylxanthone imine

(Chemical Equation Presented) The direct benzylic arylation of N-benzylxanthone imine with aryl chloride proceeds under palladium catalysis, yielding the corresponding coupling product. The product is readily transformed to benzhydrylamine. Taking into consideration that the imine is readily available from benzylic amine, the overall transformation represents a formal cross-coupling reaction of aryl halide with α-aminobenzyl metal.

Semiempirical approach to drug design. Antispasmodic activity of benzhydrylamine derivatives

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