5271-26-1

Basic information

• Product Name: 2-Phenylpiperazine
• Synonyms: 2-PHENYLPIPERAZINE;2-Phenylpiperazine 97%;Piperazine, 2-phenyl-
• CAS NO: 5271-26-1
• Molecular Formula: C₁₀H₁₄N₂
• Molecular Weight: 162.23
• EINECS: 1308068-626-2
• Product Categories: pharmacetical;Piperaizine;Piperazine derivates;Building Blocks;Heterocyclic Building Blocks;Piperazines
• Mol File: 5271-26-1.mol
• Article Data: 18

Chemical Properties

• Melting Point: 83-87 °C(lit.)
• Boiling Point: 289.2 °C at 760 mmHg
• Flash Point: 169 °C
• Appearance: /
• Density: 0.997 g/cm³
• Vapor Pressure: 0.00223mmHg at 25°C
• Refractive Index: 1.521
• PKA: 8.80±0.40(Predicted)
• CAS DataBase Reference: 2-Phenylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Phenylpiperazine(5271-26-1)
• EPA Substance Registry System: 2-Phenylpiperazine(5271-26-1)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 26-36/37
• RIDADR: UN3259
• WGK Germany: 2
• HazardClass: IRRITANT
• Hazardous Substances Data: 5271-26-1(Hazardous Substances Data)

Usage

Uses

2-Phenylpiperazine is the starting material for the synthesis of 2-phenylpiperazine compounds. It has been synthesized 1,4-dimethyl-2-phenylpiperazine, 1,4-diethyl-2-phenyl Piperazine etc.

InChI:InChI=1/C10H14N2/c1-2-4-9(5-3-1)10-8-11-6-7-12-10/h1-5,10-12H,6-8H2

Upstream product

• 21746-02-1 3-phenyl-2,5-diketopiperazine 
• 5368-28-5 2-phenyl-3-keto-piperazine 
• 1074-12-0 phenylglyoxal hydrate 
• 107-15-3 ethylenediamine 
• 1203590-16-2 4-hydroxy-3-phenyl-piperazine-1-carboxylic acid tert-butyl ester 
• 4870-65-9 2-bromophenylacetic acid 
• 2882-19-1 ethyl 2-phenyl-2-bromoacetate 
• 1421004-96-7 C₂₀H₃₀N₂O₄ 
• 100-42-5 styrene 
• 5368-34-3 (+/-)-1,4-dibenzyl-2-phenylpiperazine 
• 93-56-1 phenylethane 1,2-diol 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 163428-97-5 2-phenyl-5,6-dihydropyrazine 
• 29460-97-7 2-phenylpyrazine 

Downstream Products

• 502649-25-4 tert-butyl 4-(3-methoxy-4-(1H-pyrazol-4-yl)benzoyl)-3-phenylpiperazine-1-carboxylate 
• 185110-03-6 1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-3-phenyl-piperazine 
• 125197-43-5 1-tert-Butyl-6-fluoro-4-oxo-7-(3-phenyl-piperazin-1-yl)-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid 
• 1010740-02-9 C₁₇H₁₈N₆ 
• 1010739-58-8 C₂₀H₂₀N₆ 
• 1010739-83-9 C₂₀H₂₁N₇ 
• 1010739-65-7 C₂₁H₂₆N₆ 
• 942123-05-9 1-(4-bromo-benzyl)-3-phenyl-piperazine 
• 185108-03-6 (+,)-4-[[3,5-bis(trifluoromethyl)phenyl]acetyl]-2-phenyl-1-[[[1-(phenylmethyl)-4-piperidinyl]amino]acetyl]piperazine 
• 185107-97-5 (+/-)-4-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-phenyl-1-[[[1-(phenylmethyl)-4-piperidinyl]amino]acetyl]piperazine 

Relevant articles and documents

A simple one-pot method for the mercuric oxide mediated synthesis of piperazines via oxidative diamination of olefins

Mercuric oxide mediated one-pot synthesis of substituted piperazines via oxidative diamination of olefins with N-protected ethylene diamine has been reported. Among the various conditions tried, mercuric(II)oxide/tetrafluoroboric acid gave good to excellent yields of the desired products. A series of piperazines have been synthesized and characterized by NMR and mass spectroscopy methods.

Iridium-catalyzed condensation of amines and vicinal diols to substituted piperazines

A straightforward procedure is described for the synthesis of piperazines from amines and 1,2-diols. The heterocyclization is catalyzed by [Cp*IrCl2]2 and sodium hydrogen carbonate and can be achieved with either toluene or water as solvent. The transformation does not require any stoichiometric additives and only produces water as the byproduct. The reaction can be performed between a 1,2-diamine and a 1,2-diol or by a double condensation between a primary alkylamine and a 1,2-diol. At least one substituent is required on the piperazine ring to achieve the cyclization in good yield. The mechanism is believed to involve dehydrogenation of the 1,2-diol to the α-hydroxy aldehyde, which condenses with the amine to form the α-hydroxy imine. The latter rearranges to the corresponding α-amino carbonyl compound, which then reacts with another amine followed by reduction of the resulting imine. Piperazines are prepared by [Cp*IrCl 2]2-catalyzed heterocyclization of 1,2-diols with either 1,2-diamines or primary alkylamines. The reaction is performed in toluene or water and requires no stoichiometric additive. The key step in the mechanism is believed to be the isomerization of an α-hydroxy imine to the corresponding α-amino carbonyl compound. Copyright

AMIDO-THIOPHENE COMPOUNDS AND THEIR USE

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that, inter alia, inhibit 11 β-hydroxysteroid dehydrogenase type 1 (11 β-HSD1 ). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 11 β-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11 β-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc.