5276-76-6

Basic information

• Product Name: 4-nitrobenzyl N-[(benzyloxy)carbonyl]valinate
• CAS NO: 5276-76-6
• Molecular Formula: C₂₀H₂₂N₂O₆
• Molecular Weight: 386.3985
• Mol File: 5276-76-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 556.2°C at 760 mmHg
• Flash Point: 290.2°C
• Density: 1.244g/cm³
• Vapor Pressure: 2.07E-12mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: 4-nitrobenzyl N-[(benzyloxy)carbonyl]valinate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-nitrobenzyl N-[(benzyloxy)carbonyl]valinate(5276-76-6)
• EPA Substance Registry System: 4-nitrobenzyl N-[(benzyloxy)carbonyl]valinate(5276-76-6)

Safety Data

• Hazardous Substances Data: 5276-76-6(Hazardous Substances Data)

Upstream product

• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 619-73-8 4-nitrobenzyl chloride 

Downstream Products

• 2443-71-2 benzyl (S)-(1-hydrazineyl-3-methyl-1-oxobutan-2-yl)carbamate 
• 77313-52-1 Ac-Ser-Asp(OBzl)-Ala-Ala-Val-ONb 
• 77313-51-0 Boc-Asp(OBzl)-Ala-Ala-Val-ONb 
• 77313-53-2 Ac-Ser-Asp(OBzl)-Ala-Ala-Val-OH 
• 77313-50-9 Boc-Ala-Ala-Val-ONb 
• 40299-20-5 Boc-Ala-Val-ONb 
• 731746-19-3 H-Ala-Ala-Val-ONb 
• 769860-52-8 H-Ala-Val-ONb 
• 46925-27-3 L-valine p-nitrobenzyl ester 
• 21760-98-5 L-valine benzyl ester 
• 21356-77-4 (S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-4-carbamoyl-butyric acid 4-nitro-benzyl ester 

Relevant articles and documents

An Atom-Economic Inverse Solid-Phase Peptide Synthesis Using Bn or BcM Esters of Amino Acids

An atom-economic N-to-C-directed solid-phase peptide synthesis is reported that uses benzyl (Bn) or (benzhydryl-carbamoyl)-methyl (BcM) esters of amino acids as the building blocks, which facilitate efficient hydrazinolysis, convenient conversion to acyl azide, and robust amidation with the next amino acid ester. This method is free of coupling reagents and free of protection on the side-chain OH, CO2H, CONH2, etc., therefore exhibiting a significantly improved atom economy compared to those of BOC- or Fmoc-based C-to-N-directed approaches.