5292-53-5

Basic information

• Product Name: DIETHYL BENZYLIDENEMALONATE
• Synonyms: BENZALMALONIC ACID DIETHYL ESTER;BENZALMALONIC ACID ETHYL ESTER;BENZYLIDENEMALONIC ACID DIETHYL ESTER;DIETHYL BENZYLIDENEMALONATE;DIETHYL BENZALMALONATE;2-Benzylidene-malonic acid diethyl ester;2-Benzylidene-malonicaciddiethylester;b,b-Diethoxycarbonylstyrene
• CAS NO: 5292-53-5
• Molecular Formula: C₁₄H₁₆O₄
• Molecular Weight: 248.27
• EINECS: 226-137-8
• Mol File: 5292-53-5.mol
• Article Data: 129

Chemical Properties

• Melting Point: 28-31°C
• Boiling Point: 215-217 °C30 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.107 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00012mmHg at 25°C
• Refractive Index: n20/D 1.536(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: Insoluble in water.
• BRN: 528894
• CAS DataBase Reference: DIETHYL BENZYLIDENEMALONATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYL BENZYLIDENEMALONATE(5292-53-5)
• EPA Substance Registry System: DIETHYL BENZYLIDENEMALONATE(5292-53-5)

Safety Data

• Safety Statements: 23-24/25
• WGK Germany: 3
• Hazardous Substances Data: 5292-53-5(Hazardous Substances Data)

Usage

Uses

Diethyl benzylidenemalonate is used as a pharmaceutical intermediate. It is also involved in the Conjugate addition of cyanide ion to arylidenemalonic esters provides a useful route to arylsuccinic acids.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 3, p. 377, 1955Tetrahedron Letters, 33, p. 7535, 1992 DOI: 10.1016/S0040-4039(00)60817-1

InChI:InChI=1/C14H16O4/c1-3-17-13(15)12(14(16)18-4-2)10-11-8-6-5-7-9-11/h5-10H,3-4H2,1-2H3

Upstream product

• 110-89-4 piperidine 
• 100-52-7 benzaldehyde 
• 105-53-3 diethyl malonate 
• 108-24-7 acetic anhydride 
• 80311-86-0 (N,N-dibenzylaminobenzyl)malonate de diethyle 
• 98-87-3 benzylidene dichloride 
• 20734-18-3 diethyl 2-(hydroxymethylene)malonate 
• 64-17-5 ethanol 
• 584-45-2 2-benzylidenemalonic acid 
• 996-82-7 sodium diethylmalonate 
• 100-51-6 benzyl alcohol 
• 931-53-3 Cyclohexyl isocyanide 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 1148108-32-0 C₂₀H₂₂O₅S 

Downstream Products

• 53361-58-3 (α-piperidino-benzyl)-malonic acid diethyl ester 
• 114134-20-2 4-(2,2-bis-ethoxycarbonyl-1-phenyl-ethylamino)-benzoic acid 
• 857550-66-4 1-Hydroxy-2-(hydroxy-diphenyl-methyl)-1.3-diphenyl-indan 
• 889-38-3 N'-benzylidene-N,N-dimethyl-p-phenylenediamine 
• 6768-26-9 2-phenyl-1,1,3,3-tetraethoxycarbonylpropane 
• 37556-02-8 diethyl 2-(1-phenylpropyl)malonate 
• 149603-77-0 2-bromo-3-phenyl-valeric acid 
• 185067-05-4 ethyl 2-carbethoxy-3-cyano-3-phenylpropionate 
• 14387-18-9 3-cyano-3-phenyl propionic acid 
• 14025-83-3 3-cyano-3-phenylpropanoic acid ethyl ester 
• 5292-54-6 diethyl 2-benzhydrylmalonate 
• 500698-70-4 benzhydryl-bromo-malonic acid diethyl ester 
• 940934-46-3 diethyl (diphenylmethyl)methylmalonate 
• 858509-51-0 (+/-)-1-hydroxy-1.3-diphenyl-2-benzhydryl-indene 

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