52956-34-0Relevant articles and documents
Bisphosphonic compounds. II. Preparation of monophosphonic starting materials. Mixed esters of methylphosphonic acid
Jouko,Heikki,Esko
, p. 271 - 276 (1992)
Methyl (1-methylethyl) methylphosphonate was obtained from PCl3 via (Pr(i)O)PCl2 and (Pr(i)O)P(OMe)2 followed by the Michaelis-Arbuzov reaction with Mel. The yield was 79% with 95% chemical purity. Less reasonable conversions were obtained for some related mixed diesters.
Organophosphorus chemistry. Part 1: The synthesis of alkyl methylphosphonic acids
Timperley, Christopher M.,Bird, Michael,Holden, Ian,Black, Robin M.
, p. 26 - 30 (2007/10/03)
Several alkyl hydrogen methylphosphonates of structure RO(HO)P(O)Me were synthesised by a three-stage route [R =i-Pr, n-Bu, i-Bu, s-Bu, pinacolyl Me3C-CH(Me)-, cyclopentyl and cyclohexyl]. Trimethyl phosphite was transesterified with alcohols in the presence of sodium catalyst to give the mixed phosphites (MeO)2POR in 6-64% yield. Treatment of these with methyl iodide gave alkyl methyl methylphosphonates RO(MeO)P(O)Me in 66-95% yield. Selective demethylation of these compounds by bromotrimethylsilane, followed by methanolysis of the phosphorus silyl esters RO(Me3SiO)P(O)Me, gave the hydrogen phosphonates in 60-97% yield.