52999-15-2

Basic information

• Product Name: 3-Butyn-1-ol, 4-(4-methoxyphenyl)-
• Synonyms: 4-(4'-methoxy)phenyl-3-butyn-1-ol;4-anisylbut-3-yn-1-ol;4-(p-methoxyphenyl)-3-butyn-1-ol;4-(4-methoxyphenyl)-but-3-yn-1-ol
• CAS NO: 52999-15-2
• Molecular Formula: C11H12O2
• Molecular Weight: 176.215
• Mol File: 52999-15-2.mol
• Article Data: 32

Chemical Properties

• Melting Point: 65-66 °C
• Boiling Point: 131 °C(Press: 0.750 Torr)
• Density: 1.10±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 3-Butyn-1-ol, 4-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Butyn-1-ol, 4-(4-methoxyphenyl)-(52999-15-2)
• EPA Substance Registry System: 3-Butyn-1-ol, 4-(4-methoxyphenyl)-(52999-15-2)

Safety Data

• Hazardous Substances Data: 52999-15-2(Hazardous Substances Data)

Upstream product

• 696-62-8 para-iodoanisole 
• 927-74-2 3-Butyn-1-ol 
• 623-12-1 4-chloromethoxybenzene 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 75-21-8 oxirane 
• 768-60-5 4-methoxyphenylacetylen 
• 87639-43-8 4-(4-methoxyphenyl)but-3-yn-1-yl 4-methylbenzenesulfonate 

Downstream Products

• 25090-19-1 methyl (2E,4E)-6-(4-methoxyphenyl)-2,4-hexadienoate 
• 25090-18-0 piperovatine 
• 111168-10-6 (E)-4-Hydroxy-6-(4-methoxy-phenyl)-hex-2-enoic acid methyl ester 
• 111168-09-3 (E)-4-Acetoxy-6-(4-methoxy-phenyl)-hex-2-enoic acid methyl ester 
• 1276045-74-9 (Z)-{2-[4-ethoxy-1-(4-methoxyphenyl)but-1-en-1-yl]phenyl}(methyl)sulfane 
• 1276045-72-7 (Z)-1-[4-ethoxy-1-(4-methoxyphenyl)but-1-en-1-yl]-2-(methoxymethoxy)benzene 
• 1276045-73-8 (Z)-1-[4-ethoxy-1-(4-methoxyphenyl)but-1-en-1-yl]-2-(methoxymethoxy)naphthalene 
• 1432044-24-0 1-methoxy-4-(4-methoxybut-1-yn-1-yl)benzene 
• 1432044-15-9 2-(2-methoxyethyl)-1-(4-methoxyphenyl)pent-4-en-1-one 
• 1432044-16-0 1-methoxy-4-(4-methoxyphenyl)hept-6-en-3-one 
• 1432044-25-1 4-(4-methoxyphenyl)but-3-yn-1-yl acetate 
• 1432044-17-1 3-(4-methoxybenzoyl)hex-5-en-1-yl acetate 
• 1606590-41-3 C₁₉H₁₆O₃ 

Relevant articles and documents

Synthesis of Polysubstituted Fused Pyrroles by Gold-Catalyzed Cycloisomerization/1,2-Sulfonyl Migration of Yndiamides

Yndiamides (bis-N-substituted alkynes) are valuable precursors to azacycles. Here we report a cycloisomerization/1,2-sulfonyl migration of alkynyl-yndiamides to form tetrahydropyrrolopyrroles, unprecedented heterocyclic scaffolds that are relevant to medicinal chemistry. This functional group tolerant transformation can be achieved using Au(I) catalysis that proceeds at ambient temperature, and a thermally promoted process. The utility of the products is demonstrated by a range of reactions to functionalize the fused pyrrole core.

External Oxidant-Free Oxidative Tandem Cyclization: NaI-Catalyzed Thiolation for the Synthesis of 3-Thiosubstituted Pyrroles

A simple method for the synthesis of 3-thiosubstituted pyrroles from homopropargylic amines and thiosulfonates via a tandem sulfenylation/cyclization has been developed. The thiosulfonates are used both as substrates and oxidants in this transformation. This procedure exhibits good functional group tolerance and a series of 3-thiosubstituted pyrrole derivatives was obtained in moderate to good yields. (Figure presented.).

A General Protocol for Robust Sonogashira Reactions in Micellar Medium

A robust and general protocol for a sustainable copper-free Sonogashira cross coupling under micellar aqueous reaction conditions with high turnover was developed. By using the commercially available catalyst CataCXium A Pd G3 and THF as co-solvent, vario