53-10-1 Usage
Originator
Viadril,Pfizer,US,1957
Manufacturing Process
A solution of 20 g of desoxycorticosterone in 190 ml of absolute ethanol was
stirred in an atmosphere of hydrogen in the presence of 1.68 g of 25%
palladium on calcium carbonate catalyst. After 20 hours, approximately 1
molar equivalent of hydrogen had been absorbed and hydrogen uptake had
ceased. The catalyst was removed by filtration and the filtrate evaporated in
vacuo to yield 20 g of nearly pure product, MP 135°C to 140°C. The crude
product was demonstrated to be free of starting material by paper
chromatography. A highly purified product was obtained by recrystallization
from acetone-water with cooling in an ice bath, yield 14.5 g, MP 152°C to
154°C. The product was characterized by analysis and by absence of
ultraviolet absorption.
A solution of 14 g of 21-hydroxypregnane-3,20-dione and of 14 g of
recrystallized succinic anhydride in 140 ml of dry pyridine was allowed to
stand at room temperature for 18 hours, then cooled in an ice bath and
poured in a fine stream into 1.5 liters of ice water. Excess pyridine was
neutralized with 3N hydrochloric acid and the solution further diluted with 2
liters of ice water. The precipitated product was filtered, washed with water
and dried in vacuo at 50°C affording 18 g of solid MP 192°C to 195°C.
Recrystallization of a small sample afforded analytically pure material, MP
200°C.
Therapeutic Function
Anesthetic
Check Digit Verification of cas no
The CAS Registry Mumber 53-10-1 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 3 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 53-10:
(4*5)+(3*3)+(2*1)+(1*0)=31
31 % 10 = 1
So 53-10-1 is a valid CAS Registry Number.
InChI:InChI=1/C25H36O6.Na/c1-24-11-9-16(26)13-15(24)3-4-17-18-5-6-20(25(18,2)12-10-19(17)24)21(27)14-31-23(30)8-7-22(28)29;/h15,17-20H,3-14H2,1-2H3,(H,28,29);/q;+1/p-1/t15-,17+,18+,19+,20-,24+,25+;/m1./s1