53005-44-0

Basic information

• Product Name: 2-METHOXY-6-METHYLBENZONITRILE
• Synonyms: 2-METHOXY-6-METHYLBENZONITRILE;2-Methoxy-6-methay benzonitrile
• CAS NO: 53005-44-0
• Molecular Formula: C₉H₉NO
• Molecular Weight: 147.18
• Mol File: 53005-44-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 70-74℃ (0.4 Torr)
• Flash Point: 114.5°C
• Appearance: /
• Density: 1.06g/cm³
• Vapor Pressure: 0.00591mmHg at 25°C
• Refractive Index: 1.522
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-METHOXY-6-METHYLBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-6-METHYLBENZONITRILE(53005-44-0)
• EPA Substance Registry System: 2-METHOXY-6-METHYLBENZONITRILE(53005-44-0)

Safety Data

• Hazardous Substances Data: 53005-44-0(Hazardous Substances Data)

Usage

General Description

2-Methoxy-6-methylbenzonitrile, also known as 6-methoxy-2-methylbenzonitrile, is a chemical compound with the molecular formula C9H9NO. It is a colorless to pale yellow liquid with a faint odor, and is insoluble in water but soluble in organic solvents. It is commonly used as an intermediate in the production of pharmaceuticals, agrochemicals, and other fine chemicals. Its main applications include its use as a building block in the synthesis of various compounds, such as amides, esters, and acids. Additionally, it is known to possess antimicrobial and insecticidal properties, making it useful in the formulation of pesticides and other agricultural products. Overall, 2-methoxy-6-methylbenzonitrile plays a significant role as a versatile and valuable chemical in various industrial and agricultural processes.

InChI:InChI=1/C9H9NO/c1-7-4-3-5-9(11-2)8(7)6-10/h3-5H,1-2H3

Upstream product

• 544-92-3 copper(I) cyanide 
• 50868-73-0 2-methoxy-6-methylbenzeneamine 
• 1030446-72-0 2-methoxy-6-methylbenzaldehyde oxime 
• 773837-37-9 sodium cyanide 
• 100-84-5 1-methoxy-3-methyl-benzene 
• 22061-78-5 2-bromo-3-methylphenol 
• 38197-43-2 2-bromo-3-methylanisole 
• 54884-55-8 2-methoxy-6-methyl-benzaldehyde 
• 139583-88-3 N-propenyl-2-methoxy-6-methylbenzamide 
• 139583-86-1 N-propenyl-o-methoxybenzamide 
• 66897-24-3 o-methoxy-N-allylbenzamide 
• 139583-90-7 2-methoxy-6-methylbenzamide 

Downstream Products

• 256526-06-4 2-Methoxy-6-(2-oxopropyl)benzonitrile 
• 1408089-50-8 1-(2-methoxy-6-methylphenyl)-2-phenylethanone 
• 137937-39-4 1-(2-hydroxy-6-methylphenyl)-2-phenylethanone 
• 1408089-52-0 2-(1-(benzyloxy)ethyl)-5-methyl-3-phenyl-4H-chromen-4-one 
• 1408089-54-2 2-(1-hydroxyethyl)-5-methyl-3-phenyl-4H-chromen-4-one 
• 1374574-57-8 3-bromo-6-methoxy-2-methylbenzonitrile 
• 1431944-47-6 3-(bromoacetyl)-6-methoxy-2-methylbenzonitrile 
• 1431944-48-7 C₂₀H₂₅N₃O₅ 
• 1431944-45-4 6-methoxy-2-methyl-3-[{2-oxopiperazin-1-yl}acetyl]benzonitrile 
• 1431943-78-0 3-({4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2-oxopiperazin-1-yl}acetyl)-6-methoxy-2-methylbenzonitrile 
• 1443739-14-7 tert-butyl (3S)-4-[2-(3-cyano-4-methoxy-2-methylphenyl)-2-oxoethyl]-3-(hydroxymethyl)piperazine-1-carboxylate 
• 1443738-96-2 tert-butyl (3R,9aS)-3-(3-cyano-4-methoxy-2-methylphenyl)hexahydropyrazino[2,1-c][1,4]oxazine-8(1H)-carboxylate 
• 1431944-46-5 3-acetyl-6-methoxy-2-methylbenzonitrile 
• 73289-66-4 2-hydroxy-6-methylbenzonitrile 

Relevant articles and documents

Electrochemical C-H cyanation of electron-rich (Hetero)arenes

A straightforward method for the electrochemical C-H cyanation of arenes and heteroarenes that proceeds at room temperature in MeOH, with NaCN as the reagent in a simple, open, undivided electrochemical cell is reported. The platinum electrodes are passivated by ad-sorbed cyanide, which allows conversion of an exceptionally broad range of electron-rich substrates all the way down to dialkyl arenes. The cyanide electrolyte can be replenished with HCN, opening opportunities for salt-free industrial C-H cyanation.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir 1.1) channel. The compounds act as diuretics and natriuretics and are valuable pharmaceutically active compounds for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension and conditions resulting from excessive salt and water retention.

NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES

The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.