530080-17-2

Basic information

• Product Name: 4-(2,2,2-TRIFLUOROETHOXY)IODOBENZENE
• Synonyms: 4-(2,2,2-TRIFLUOROETHOXY)IODOBENZENE;1-IODO-4-(2,2,2-TRIFLUOROETHOXY)BENZENE;1-Iodo-4-(2,2,2-trifluoroethoxy)benzene, 4-Iodophenyl 2,2,2-trifluoroethyl ether;4-Iodo-beta,beta,beta-trifluorophenetole
• CAS NO: 530080-17-2
• Molecular Formula: C8H6F3IO
• Molecular Weight: 302.03
• Mol File: 530080-17-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 236.0±40.0 °C(Predicted)
• Appearance: /
• Density: 1.793±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-(2,2,2-TRIFLUOROETHOXY)IODOBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2,2,2-TRIFLUOROETHOXY)IODOBENZENE(530080-17-2)
• EPA Substance Registry System: 4-(2,2,2-TRIFLUOROETHOXY)IODOBENZENE(530080-17-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 530080-17-2(Hazardous Substances Data)

Usage

General Description

4-(2,2,2-TRIFLUOROETHOXY)IODOBENZENE is a chemical compound with the molecular formula C8H6F3IO. It is a benzene derivative that contains an iodo group and a trifluoroethoxy group. 4-(2,2,2-TRIFLUOROETHOXY)IODOBENZENE is used as a reagent in various chemical reactions, particularly in organic synthesis and medicinal chemistry. It is known for its ability to introduce an iodo group into other organic compounds, making it a valuable tool for researchers and chemists. 4-(2,2,2-TRIFLUOROETHOXY)IODOBENZENE is a versatile and important chemical that plays a significant role in the development of pharmaceuticals and other high-value organic molecules.

Upstream product

• 75-89-8 2,2,2-trifluoroethanol 
• 5122-99-6 4-iodophenylboronic acid 
• 353-83-3 1,1,1-trifluoro-2-iodoethane 
• 540-38-5 p-Iodophenol 

Relevant articles and documents

Metal-free transfer hydrochlorination of internal C-C triple bonds with a bicyclo[3.1.0]hexane-based surrogate releasing two molecules of hydrogen chloride

The development and application of a transfer hydrochlorination reagent based on a trichlorinated bicyclo[3.1.0]hexane core that transfers two molecules of HCl per molecule of surrogate to a π-basic substrate under B(C6F5)3 catalysis is reported. Lewis acid-assisted chloride abstraction followed by thermal electrocyclic cyclopropyl-to-allyl cation ring opening releases ring strain as a previously unexploited driving force.

Method for preparing aryl trifluoroethoxyl ether

The invention relates to a method for preparing aryl trifluoroethoxyl ether. The method includes the steps that aryl boron compounds and trifluoroethanol are added to organic solvent, a copper salt catalyst, a ligand and an oxidizing agent are added, a reaction is conducted in a stirring mode for 1-40 hours at the temperature of 0-60 DEG C, filtering is conducted, column chromatography isolation is conducted, and the aryl trifluoroethoxyl ether is obtained. The method is simple in operation, raw materials are easy to obtain, the reaction condition is mild, the substrate universality is wide, the environmental friendliness is achieved, and the method is applicable to industrial application.