53039-63-7

Basic information

• Product Name: 4-METHOXY-3'-METHYLBENZOPHENONE
• Synonyms: 4-METHOXY-3'-METHYLBENZOPHENONE;OTAVA-BB 1043926;UKRORGSYN-BB BBV-5119093
• CAS NO: 53039-63-7
• Molecular Formula: C₁₅H₁₄O₂
• Molecular Weight: 226.27
• Mol File: 53039-63-7.mol
• Article Data: 24

Chemical Properties

• Melting Point: 55–56°C
• Boiling Point: 373°C at 760 mmHg
• Flash Point: 168.5°C
• Appearance: /
• Density: 1.088g/cm³
• Vapor Pressure: 9.25E-06mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: 4-METHOXY-3'-METHYLBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXY-3'-METHYLBENZOPHENONE(53039-63-7)
• EPA Substance Registry System: 4-METHOXY-3'-METHYLBENZOPHENONE(53039-63-7)

Safety Data

• Hazardous Substances Data: 53039-63-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H14O2/c1-11-4-3-5-13(10-11)15(16)12-6-8-14(17-2)9-7-12/h3-10H,1-2H3

Upstream product

• 874-90-8 4-methoxybenzonitrile 
• 28987-79-3 m-tolylmagnesium bromide 
• 696-62-8 para-iodoanisole 
• 1711-06-4 3-Methylbenzoyl chloride 
• 213596-33-9 2-(4-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborolane 
• 67-66-3 chloroform 
• 201230-82-2 carbon monoxide 
• 17933-03-8 m-tolylboronic acid 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 62381-20-8 2-(3-methylphenyl)-1,3-dithiane 
• 794-94-5 p-Methoxybenzoic anhydride 
• 68971-88-0 Tributyl-m-tolyl-stannane 
• 100-07-2 4-methoxy-benzoyl chloride 
• 591-17-3 meta-bromotoluene 

Downstream Products

• 37825-77-7 (4-methoxyphenyl)(m-tolyl)methanol 
• 136326-43-7 3-bromomethyl-[4'-methoxy]-benzophenone 
• 71372-37-7 4-hydroxy-3’-methylbenzophenone 
• 66938-63-4 (4-Amino-3-nitro-phenyl)-m-tolyl-methanone 
• 75607-26-0 (4-Dimethylamino-phenyl)-(4-methoxy-phenyl)-m-tolyl-methanol 
• 66938-43-0 (4-Methoxy-3-nitro-phenyl)-m-tolyl-methanone 

Relevant articles and documents

Silylcarboxylic Acids as Bifunctional Reagents: Application in Palladium-Catalyzed External-CO-Free Carbonylative Cross-Coupling Reactions

A palladium-catalyzed external-CO-free carbonylative Hiyama-Denmark cross-coupling reaction is presented. The introduction of silylcarboxylic acids as bifunctional reagents (CO and nucleophile source) avoids the need for external gaseous CO and a silylarene coupling partner. The transformation features high functional group tolerance and it is successful with electron-rich, -neutral, and -poor aryl iodides. Stoichiometric studies and control experiments provide insight into the reaction mechanism and support the hypothesized dual role of silylcarboxylic acids. (Figure presented.).

Ni-Catalyzed cross-coupling reactions of N-acylpyrrole-type amides with organoboron reagents

The catalytic conversion of amides to ketones is highly desirable yet challenging in organic synthesis. We herein report the first Ni/bis-NHC-catalyzed cross-coupling of N-acylpyrrole-type amides with arylboronic esters to obtain diarylketones. This method is facilitated by a new chelating bis-NHC ligand. The reaction tolerates diverse functional groups on both arylamide and arylboronic ester partners including sensitive ester and ketone groups.

Iron-catalyzed carbonylation of aryl halides with arylborons using stoichiometric chloroform as the carbon monoxide source

A general iron-catalyzed carbonylative Suzuki-Miyaura coupling of aryl halides with arylborons is reported, using stoichiometric CHCl3 as the CO source. The high efficiency, economy, selectivity, and operational simplicity of this transformation make this method a valuable tool in organic synthesis. Importantly, the presented strategy allows effective 13C labeling simply by using the commercially available 13C-labeled CHCl3. On the basis of the initial mechanistic exploration, an aryl radical intermediate is proposed in the present carbonylation process.