53081-30-4Relevant articles and documents
A synthetic acceptor substrate for Trypanosoma brucei UDP-Gal : GPI anchor side-chain α-galactosyltransferases
Brown, Jillian R.,Smith, Terry K.,Ferguson, Michael A.J.,Field, Robert A.
, p. 2051 - 2054 (1998)
A synthetic analogue of a trisaccharide fragment of the Trypanosoma brucei Variant Surface Glycoprotein (VSG) GlycosylPhosphatidylInositiol (GPI) anchor, Gal-α-l,3(Man-α-1,6)-Man-α-O-octyl (1), serves as a substrate for two T. brucei α-galactosyltransfera
Indolylthio glycosides as effective building blocks for chemical glycosylation
Demchenko, Alexei V.,Shrestha, Ganesh,Panza, Matteo,Singh, Yashapal,Rath, Nigam P.
, p. 15885 - 15894 (2021/01/19)
The S-indolyl (SIn) anomeric moiety was investigated as a new leaving group that can be activated for chemical glycosylation under a variety of conditions including thiophilic and metal-assisted pathways. Understanding of the reaction pathways for the SIn moiety activation was achieved via the extended mechanistic study. Also reported is how the new SIn donors fit into selective activation strategies for oligosaccharide synthesis.
β-Selective One-Pot Synthesis of Acyl-C-Glycosides via Corey-Seebach Umpolung Reaction
Boehlich, G. Jacob,Schützenmeister, Nina
, p. 1935 - 1939 (2019/10/22)
C-Glycosides are commonly used as carbohydrate mimics in drug development due to their stability against enzymatic and chemical hydrolysis. In this Synpacts article we elaborate on our fast and efficient β-selective approach towards protected and unprotected acyl glycosides. Application of a Corey-Seebach umpolung reaction enables the exclusive formation of the β-Anomer of aromatic acyl-C-glycosides in good to excellent yields. 1 Introduction 2 C-Glycosylation of Benzylated Glycosyl Donors 3 C-Glycosylation of Silylated Glycosyl Donors 4 Conclusion.