53172-91-1Relevant articles and documents
Optimized catalytic enantioselective aryl transfer process gives access to mGlu2 receptor potentiators
Magnus, Nicholas A.,Anzeveno, Peter B.,Coffey, D. Scott,Hay, David A.,Laurila, Michael E.,Schkeryantz, Jeffrey M.,Shaw, Bruce W.,Staszak, Michael A.
, p. 560 - 567 (2007)
An asymmetric enantioselective aryl transfer reaction was developed to give access to the diarylmethanol 7 and ultimately acetate 2 which is useful for the preparation of mGlu2 receptor potentiators (Scheme 3). The aryl transfer chemistry involved the pre
Cationic Dirhodium Complexes Bridged by 2-Phosphinopyridines Having an Exquisitely Positioned Axial Shielding Group: A Molecular Design for Enhancing the Catalytic Activity of the Dirhodium Core
Ohnishi, Ryuhei,Ohta, Hidetoshi,Mori, Shigeki,Hayashi, Minoru
, p. 2678 - 2690 (2021/07/31)
This report describes a strategy to create highly electrophilic dirhodium catalysts. The electrophilicity of lantern-Type dirhodium complexes is generally decreased by the coordination of a ligand to the axial site, which often causes a reduction in the catalytic activity. We designed and synthesized a series of cationic dirhodium complexes bridged by 2-diarylphosphinopyridines having a bulky 2,4,6-Triisopropylphenyl (Tip) group that can prevent the attack of external molecules to the closest axial site. Theoretical calculations indicated that the Tip group weakly interacts with the axial site but hardly reduces the electrophilicity of the dirhodium core. The complexes served as excellent catalyst precursors for the dehydrogenative silylation of alcohols using hydrosilanes under mild conditions and a low metal loading, producing the silyl ethers in higher yields in comparison to conventional dirhodium complexes.
Use of Silylated Formiates as Hydrosilane Equivalents
-
Paragraph 0514, (2021/09/26)
The present invention relates to a method for preparing organic compounds of formula (I) by reaction between a silylated formiate of formula (II) and an organic compound in the presence of a catalyst and optionally of an additive. The invention also relates to use of the method for preparing organic compounds of formula (I) for the preparation of reagents for fine chemistry and for heavy chemistry, as well as in the production of vitamins, pharmaceutical products, adhesives, acrylic fibres, synthetic leathers, and pesticides.
Catalytic reduction of aryl trialkylammonium salts to aryl silanes and arenes
Rand, Alexander W.,Montgomery, John
, p. 5338 - 5344 (2019/05/29)
A new approach for the reduction of aryl ammonium salts to arenes or aryl silanes using nickel catalysis is reported. This method displays excellent ligand-controlled selectivity based on the N-heterocyclic carbene (NHC) ligand employed. Utilizing a large NHC in non-polar solvents generates aryl silanes, while small NHCs in polar solvents promote reduction to arenes. Several classes of aryl silanes can be accessed from simple aniline building blocks, including those useful for cross-couplings, oxidations, and halogenations. The reaction conditions are mild, functional group tolerant, and provide efficient access to a variety of benzene derivatives.
