53312-79-1

Basic information

• Product Name: 3-AMINO-4-CHLOROBENZONITRILE
• Synonyms: 2-CHLORO-5-CYANO-ANILINE;3-AMINO-4-CHLOROBENZONITRILE;3-Amino-4-chlorobenzonitrile 96%
• CAS NO: 53312-79-1
• Molecular Formula: C₇H₅ClN₂
• Molecular Weight: 152.58
• EINECS: 258-471-5
• Product Categories: Aromatic Nitriles;C6 to C7;Cyanides/Nitriles;Nitrogen Compounds;Building Blocks;C6 to C7;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 53312-79-1.mol
• Article Data: 13

Chemical Properties

• Melting Point: 87-91 °C
• Boiling Point: 292 °C at 760 mmHg
• Flash Point: 130.4 °C
• Appearance: /
• Density: 1.33 g/cm³
• Vapor Pressure: 0.00188mmHg at 25°C
• Refractive Index: 1.609
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: soluble in Methanol
• PKA: 0.85±0.10(Predicted)
• CAS DataBase Reference: 3-AMINO-4-CHLOROBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-4-CHLOROBENZONITRILE(53312-79-1)
• EPA Substance Registry System: 3-AMINO-4-CHLOROBENZONITRILE(53312-79-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38-43
• Safety Statements: 26-36/37
• RIDADR: 3439
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 53312-79-1(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 36, p. 9305, 1995 DOI: 10.1016/0040-4039(95)02003-8

InChI:InChI=1/C7H5ClN2/c8-6-2-1-5(4-9)3-7(6)10/h1-3H,10H2

Upstream product

• 939-80-0 4-chloro-3-nitrobenzonitrile 
• 623-03-0 4-Cyanochlorobenzene 
• 7732-18-5 water 

Downstream Products

• 721450-86-8 4-(2-Chloro-5-cyano-phenylamino)-butyric acid methyl ester 
• 1202512-61-5 6-cyano-3-methyl-1H-indole 
• 1202512-84-2 3-(allylamino)-4-chlorobenzonitrile 
• 1939-76-0 4-chloro-3-sulfamoylbenzonitrile 
• 942199-56-6 2-chloro-5-cyanobenzene-1-sulfonyl chloride 
• 401567-16-6 5-cyano-2-methylthiobenzothiazole 
• 1431959-23-7 N-(5-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-2-chlorophenyl)acrylamide trifluoroacetate 
• 1431960-51-8 C₁₆H₁₆ClN₅S 
• 1401460-87-4 5-chloro-N-(2-chloro-5-cyanophenyl)-2-hydroxybenzamide 
• 1239578-83-6 4-Chloro-3-(1-nitro-2-naphthylamino)benzonitrile 

Relevant articles and documents

Research on controllable degradation of sulfonylurea herbicides

In order to seek ecologically safer and environmentally benign sulfonylurea herbicides (SU), insight into the structure/bioassay/soil degradation tri-factor relationship was first established. With the introduction of various groups (alkyl, nitro, halogen, cyano etc.) at the 5th position of its benzene ring, structural derivatives of chlorsulfuron were designed, synthesized, and evaluated for their herbicidal activity. The structures of the title compounds were confirmed by infrared spectroscopy, ultraviolet spectroscopy, 1H and 13C NMR, mass spectrometry, elemental analysis and X-ray diffraction. Bioassay results confirmed that most derivatives retained their superior herbicidal activities in comparison with chlorsulfuron. After investigating the soil degradation behavior of each molecule under set conditions, it was found that structures with electron-withdrawing substituents at the 5th position of the benzene ring retained their long degradation half-lives, yet the introduction of electron-donating substituents accelerated the degradation rate. These results will provide a valuable clue to further explore the potential controllable degradation of SU and other herbicides, and to discover novel herbicides that are favorable for environmentally and ecologically sustainable development.

In situ production of silver nanoparticles on an aldehyde-equipped conjugated porous polymer and subsequent heterogeneous reduction of aromatic nitro groups at room temperature

In a metal-free procedure, chelating thiol groups and an electrophile react to assemble a robust, conjugated porous polymer with pendant aldehyde functionalities. These groups are able to reduce Ag(I) ions to generate, in situ, Ag(0) nanoparticles evenly dispersed in the polymer matrix. The Ag(0)-polymer composite enables selective reduction of aromatic nitro compounds as a heterogeneous catalyst, and can be conveniently recycled multiple times.

THERAPEUTIC AGENT FOR CEREBRAL INFARCTION

The invention provides a therapeutic drug for ischemic stroke. The therapeutic drug has the formula (I) wherein each symbol is as defined herein, or a pharmacologically acceptable salt thereof, or a solvate thereof, as an active ingredient.