53312-80-4

Basic information

• Product Name: 4-AMINO-2-FLUOROBENZONITRILE
• Synonyms: 4-Amino-2-fluorobenzonitrile;Fluoro-4-amino-benzonitrile
• CAS NO: 53312-80-4
• Molecular Formula: C₇H₅FN₂
• Molecular Weight: 136.13
• Product Categories: Phenyls & Phenyl-Het
• Mol File: 53312-80-4.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 288.231 °C at 760 mmHg
• Flash Point: 128.118 °C
• Appearance: /
• Density: 1.256 g/cm³
• Vapor Pressure: 0.00237mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: 2-8°C(protect from light)
• PKA: 0.71±0.10(Predicted)
• CAS DataBase Reference: 4-AMINO-2-FLUOROBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-2-FLUOROBENZONITRILE(53312-80-4)
• EPA Substance Registry System: 4-AMINO-2-FLUOROBENZONITRILE(53312-80-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 53312-80-4(Hazardous Substances Data)

Usage

Chemical Properties

Off-white crystalline

InChI:InChI=1/C7H5FN2/c8-7-3-6(10)2-1-5(7)4-9/h1-3H,10H2

Upstream product

• 34667-88-4 2-fluoro-4-nitrobenzonitrile 
• 3939-09-1 2,4-difluorobenzonitrile 
• 1427-07-2 2-fluoro-4-nitrotoluene 
• 403-24-7 2-fluoro-4-nitrobenzoic acid 
• 350-32-3 2-fluoro-4-nitrobenzamide 
• 403-23-6 2-fluoro-4-nitrobenzoyl chloride 
• 584-48-5 2,4-dinitrobromobenzene 
• 108-86-1 bromobenzene 
• 4110-33-2 2,4-dinitrobenzonitrile 
• 1338209-74-7 N-(4-cyano-3-fluorophenyl)-2-methylpropane-2-sulfinamide 
• 105942-08-3 4-bromo-6-fluorobenzonitrile 
• 557-21-1 zinc(II) cyanide 
• 656-65-5 3-fluoro-4-bromophenylamine 

Downstream Products

• 1008714-39-3 4-amino-2-(4-hydroxy-cyclohexylamino)-benzonitrile 
• 171049-40-4 2-fluoro-4-(methylamino)benzonitrile 
• 881674-66-4 4-cyano-3-fluorobenzene-1-sulfonyl chloride 
• 446-31-1 2-fluoro-4-aminobenzoic acid 
• 86776-54-7 3-fluoro-4-cyanophenyl-4'-n-heptylbenzoate 
• 86786-89-2 3-fluoro-4-cyanophenyl-4'-n-pentylbenzoate 
• 86776-52-5 3-fluoro-4-cyanophenyl-4'-n-butylbenzoate 

Relevant articles and documents

NOVEL TETRAZOLE COMPOUNDS AND THEIR USE IN THE TREATMENT OF TUBERCULOSIS

The invention relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof and their use in therapy, for example in the treatment of mycobacterial infections or in the treatment of diseases caused by mycobacterium, such as tuberculosis.

Proton pump inhibitors

A proton pump inhibitor containing a compound represented by the formula (I) wherein X and Y are the same or different and each is a bond or a spacer having 1 to 20 carbon atoms in the main chain, R 1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, R 2 , R 3 and R 4 are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted thienyl group, an optionally substituted benzo[b]thienyl group, an optionally substituted furyl group, an optionally substituted pyridyl group, an optionally substituted pyrazolyl group, an optionally substituted pyrimidinyl group, an acyl group, a halogen atom, a cyano group or a nitro group, R 5 and R 6 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, which has a superior proton pump action and shows an antiulcer activity and the like after conversion to a proton pump inhibitor in the body, or a salt thereof. or a prodrug thereof is provided.

Efficient indoles and anilines syntheses employing tert-butyl sulfinamide as ammonia surrogate

tert-Butyl sulfinamide is an ammonia equivalent for the palladium-catalyzed amination of aryl bromides and aryl chlorides. Using these amine derivatives, it has been observed that indoles and anilines with sensitive functional groups can be readily prepared. This surrogate has also been used for the synthesis of indoles from 2-halophenols using palladium catalyzed cross coupling reaction as the key step.