5337-04-2

Basic information

• Product Name: tetrahydropyran-4,4-dicarboxylic acid
• Synonyms: tetrahydropyran-4,4-dicarboxylic acid;4,4-Tetrahydropyrandicarboxylic Acid;Dihydro-2H-pyran-4,4(3H)-dicarboxylic acid;tetrahydro-4H-pyran-4,4-dicarboxylic acid;oxane-4,4-dicarboxylic acid
• CAS NO: 5337-04-2
• Molecular Formula: C7H10O5
• Molecular Weight: 174.1513
• Mol File: 5337-04-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 87 °C
• Boiling Point: 412.3°Cat760mmHg
• Flash Point: 176°C
• Appearance: /
• Density: 1.446g/cm³
• Vapor Pressure: 5.91E-08mmHg at 25°C
• Refractive Index: 1.522
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.75±0.20(Predicted)
• CAS DataBase Reference: tetrahydropyran-4,4-dicarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: tetrahydropyran-4,4-dicarboxylic acid(5337-04-2)
• EPA Substance Registry System: tetrahydropyran-4,4-dicarboxylic acid(5337-04-2)

Safety Data

• Hazardous Substances Data: 5337-04-2(Hazardous Substances Data)

Usage

General Description

Tetrahydropyran-4,4-dicarboxylic acid is a chemical compound with the molecular formula C7H10O4. It is a dicarboxylic acid containing a tetrahydropyran ring, which is a six-membered cyclic ether with an oxygen atom. tetrahydropyran-4,4-dicarboxylic acid is used in organic synthesis as a building block for various pharmaceuticals and agrochemicals. It is also utilized in the production of polymers and as a ligand in coordination chemistry. Tetrahydropyran-4,4-dicarboxylic acid has potential applications in the development of new materials and medicinal compounds due to its unique structure and reactivity.

InChI:InChI=1/C7H10O5/c8-5(9)7(6(10)11)1-3-12-4-2-7/h1-4H2,(H,8,9)(H,10,11)

Upstream product

• 30431-99-3 4-cyano-tetrahydro-pyran-4-carboxylic acid ethyl ester 
• 111511-90-1 dihydro-2H-pyran-4,4(3H)-dicarbonitrile 
• 111-44-4 3-oxa-1,5-dichloropentane 
• 108-59-8 malonic acid dimethyl ester 
• 34270-90-1 2,2'-diiodoethyl ether 
• 105-53-3 diethyl malonate 
• 5382-77-4 tetrahydro-pyran-4,4-dicarboxylic acid diethyl ester 

Downstream Products

• 128094-82-6 tetrahydro-thiopyran-4-carboxylic acid methyl ester 
• 100277-27-8 (tetrahydro-2H-thiopyran-4-yl)methanol 
• 195503-55-0 (1-Methyl-1-{4-[1-methyl-1-(methyl-phenyl-carbamoyl)-ethylcarbamoyl]-tetrahydro-pyran-4-ylcarbamoyl}-ethyl)-carbamic acid benzyl ester 
• 195503-53-8 {1-Methyl-1-[4-(methyl-phenyl-carbamoyl)-tetrahydro-pyran-4-ylcarbamoyl]-ethyl}-carbamic acid benzyl ester 
• 195503-54-9 4-(2-Benzyloxycarbonylamino-2-methyl-propionylamino)-tetrahydro-pyran-4-carboxylic acid 
• 195503-45-8 N-methyl-N-phenyl-6-oxa-1-azaspiro[2.5]oct-1-en-2-amine 
• 26170-23-0 tetrahydro-N-methyl-N-phenyl-2H-pyran-4-carboxamide 
• 40191-32-0 tetrahydro-2H-pyran-4-carbonylchloride 
• 5337-03-1 tetrahydro-2H-pyran-4-carboxylic acid 

Relevant articles and documents

2-OXO-2- (2-PHENYL-5,6,7,8-TETRAHYDRO-INDOLIZIN-3-YL) -ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ANTIFUNGAL AGENTS

The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof: wherein: R1, R2, R3, R4, R5, R6, R7, R8, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in the manufacture of medicaments for use in the prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.

METHOD FOR PRODUCING NITRILE COMPOUND, CARBOXYLIC ACID COMPOUND OR CARBOXYLATE COMPOUND

The present invention discloses a process for preparing a nitrile compound, a carboxylic acid compound or a carboxylic acid ester compound represented by the formula (2): wherein R represents a cyano group, a carboxyl group or an ester group, R1 and R2 each represent a group which does not participate in the reaction, which may have a substituent, and R1 and R2 may be combined to each other to form a ring, which comprises subjecting an acetic acid compound represented by the formula (1): wherein R, R1 and R2 have the same meanings as defined above, to decarboxylation in the presence of a metal catalyst.

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Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release (e.g., Parkinsonism, Parkinson's Disease, Tourette's Syndrome, attention deficient disorder, or schizophrenia), are treated by administering a 1-aza-2-(3-pyridyl)bicyclo[2.2.1]heptane, a 1-aza-2-(3-pyridyl)bicyclo[2.2.2]octane, a 1-aza-2-(3-pyridyl)bicyclo[3.2.1]octane, a 1-aza-2-(3-pyridyl)bicyclo[3.2.2]nonane, a 1-aza-7-(3-pyridyl) bicyclo[2.2.1]heptane, a 1-aza-3-(3-pyridyl)bicyclo[3.2.2]nonane, or a 1-aza-7-(3-pyridyl)bicyclo[3.2.2]nonane. The compounds can exist as individual stereoisomers, racemic mixtures, diastereomers and the like.