53435-01-1

Basic information

• Product Name: 1-chloro-3-(4-chloro-3-methylphenoxy)propan-2-ol
• CAS NO: 53435-01-1
• Molecular Weight: 235.11
• Mol File: 53435-01-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-chloro-3-(4-chloro-3-methylphenoxy)propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-3-(4-chloro-3-methylphenoxy)propan-2-ol(53435-01-1)
• EPA Substance Registry System: 1-chloro-3-(4-chloro-3-methylphenoxy)propan-2-ol(53435-01-1)

Safety Data

• Hazardous Substances Data: 53435-01-1(Hazardous Substances Data)

Upstream product

• 59-50-7 4-Chloro-3-methylphenol 
• 106-89-8 epichlorohydrin 

Relevant articles and documents

Improvement and simplification of synthesis of 3-aryloxy-1,2-epoxypropanes using solvent-free conditions and microwave irradiations. Relation with medium effects and reaction mechanism

Some 3-aryloxy-1,2-epoxypropanes, interesting as potential synthons in β-adrenergic receptor antagonists preparation, were obtained in excellent yields (65-96% within 2-17 min) by microwave activation (monomode system) using solid-liquid solvent-free phase transfer catalysis (PTC). The best results for the O-alkylation of some phenols with epichlorohydrin were obtained using TBAB and NaOH/K2CO3 (1:4 mol/mol) as phase transfer catalyst and more acceptable basic system, respectively. These new procedure is compared with classical methods. Significant specific microwave effect (non-purely thermal) was evidenced in all cases. They were discussed in terms of reaction medium and mechanism, taking into account the variations in polarity of the systems.