53448-09-2

Basic information

• Product Name: D-Leucinol
• Synonyms: (R)-2-AMino-4-Methylpentan-1-ol;(R)-2-aMino-4-Methylpentan-1-ol/R-Lucinol;D(-)-Leucinol, 97% ee, 97% 5GR;(2R)-2-AMino-4-Methyl-1-pentanol;(2R)-4-Methylpentane-1-hydroxy-2-aMine;(2R)-2-Amino-4-methylpentan-1-ol;D-Leucinol 98%;(R)-(-)-Leucinol 98%
• CAS NO: 53448-09-2
• Molecular Formula: C₆H₁₅NO
• Molecular Weight: 117.1894
• EINECS: 217-975-5
• Product Categories: Amino Acids & Derivatives;Aromatics;Chiral Reagents;Intermediates;Amino Acids & Derivatives, Aromatics, Chiral Reagents, Intermediates;Leucine [Leu, L];Chiral Compound;Amino alcohols
• Mol File: 53448-09-2.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 198-200 °C768 mm Hg(lit.)
• Flash Point: 195 °F
• Appearance: clear pale yellow viscous liquid
• Density: 0.917 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0897mmHg at 25°C
• Refractive Index: n20/D 1.450
• Storage Temp.: 0-6°C
• PKA: 12.88±0.10(Predicted)
• Sensitive: Air Sensitive
• BRN: 1719241
• CAS DataBase Reference: D-Leucinol(CAS DataBase Reference)
• NIST Chemistry Reference: D-Leucinol(53448-09-2)
• EPA Substance Registry System: D-Leucinol(53448-09-2)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34-22-36/37/38-36/38
• Safety Statements: 23-24/25-45-36/37/39-26-27-37
• RIDADR: NA 1993 / PGIII
• WGK Germany: 3
• F: 2-10
• Hazardous Substances Data: 53448-09-2(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 53448-09-2 differently. You can refer to the following data:
1. Potent antiproliferative agent, exhibits growth inhibition and induction in melanoma cells. Efficient organocatalysts for the cross-aldol reaction of isatin and its derivatives.
2. Potent antiproliferative agent, exhibits growth inhibition and induction in melanoma cells. Efficient organocatalysts for the cross-aldol reaction of isatin and its derivatives.

InChI:InChI=1/C6H15NO/c1-5(2)3-6(7)4-8/h5-6,8H,3-4,7H2,1-2H3/p+1/t6-/m1/s1

Upstream product

• 37763-22-7 D-leucine ethyl ester 
• 328-38-1 (R)-leucine 
• 73913-65-2 D-(-)-leucine ethyl ester hydrochloride 
• 5845-53-4 (R)-leucine methyl ester hydrochloride 
• 23032-21-5 D-leucine methyl ester 
• 4071-36-7 ethyl N-acetyl-leucinate 

Downstream Products

• 13892-89-2 (R)-2-amino-1-bromo-4-methylpentane hydrobromide 
• 329229-80-3 (2R)-2-(2-fluoro-4-nitrophenyl)amino-4-methyl-1-pentanol 
• 215436-07-0 (R)-2-(1-hydroxy-4-methylpentan-2-yl)isoindoline-1,3-dione 
• 321329-46-8 C₁₃H₂₀ClNO 
• 88129-47-9 [(R)-4-Methyl-2-(toluene-4-sulfonylamino)-pentyl]-phosphonic acid diethyl ester 
• 87601-33-0 Methyl-[(R)-4-methyl-2-(toluene-4-sulfonylamino)-pentyl]-phosphinic acid ethyl ester 
• 502545-85-9 N-(4-fluorophenylsulfonyl)-L-valyl-D-leucinol 
• 190275-62-8 N-(4-fluorophenylsulfonyl)-D-valyl-D-leucinol 
• 307532-07-6 (2R)-2-(dibenzylamino)-4-methylpentan-1-ol 
• 87601-32-9 Toluene-4-sulfonic acid (R)-4-methyl-2-(toluene-4-sulfonylamino)-pentyl ester 
• 86941-40-4 (R)-2-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-4-methyl-pentan-1-ol 

Relevant articles and documents

Enantio- and Diastereodivergent Sequential Catalysis Featuring Two Transition-Metal-Catalyzed Asymmetric Reactions

This study demonstrates the feasibility and inherent benefits of combining two distinct asymmetric transition-metal-catalyzed reactions in one pot. The reported transformation features a Pd-catalyzed asymmetric allylic alkylation and a Rh-catalyzed enantioselective 1,4-conjugate addition, effectively converting simple allyl enol carbonate precursors into enantioenriched cyclic ketones with two remote stereocenters. Despite the anticipated challenges associated with controlling stereoselectivity in such a complex system, the products are obtained in enantiomeric excesses ranging up to >99 % ee, exceeding those obtained from either of the individual asymmetric reactions. In addition, since the stereoselectivity of both steps is under catalyst control, this one-pot reaction is enantio- and diastereodivergent, enabling facile access to all stereoisomers from the same set of starting materials.

Design, Synthesis, Fungicidal Activity, and Unexpected Docking Model of the First Chiral Boscalid Analogues Containing Oxazolines

Chirality greatly influences the biological and pharmacological properties of a pesticide and will contribute to unnecessary environmental loading and undesired ecological impact. No structure and activity relationship (SAR) of enantiopure succinate dehydrogenase inhibitors (SDHIs) was documented during the structure optimization of boscalids. On the basis of commercial SDHIs, oxazoline natural products, and versatile oxazoline ligands in organic synthesis, the first effort was devoted to explore the chiral SDHIs and the preliminary mechanism thereof. Fine-tuning furnished chiral nicotinamides 4ag as a more promising fungicidal candidate against Rhizoctonia solani, Botrytis cinerea, and Sclerotinia sclerotiorum, with EC50 values of 0.58, 0.42, and 2.10 mg/L, respectively. In vivo bioassay and molecular docking were investigated to explore the potential in practical application and plausible novelty in action mechanism, respectively. The unexpected molecular docking model showed the different chiral effects on the binding site with the amino acid residues. This chiral nicotinamide also featured easy synthesis and cost-efficacy. It will provide a powerful complement to the commercial SDHI fungicides with the introduction of chirality.

The first synthesis of β-amino phosphonates using cyclic sulfamidates

Cyclic sulfamidates (prepared from α-amino acids and β-amino alcohols) have been used for the first time for the synthesis of novel β-amino phosphonates (chiral and achiral) by treatment with dialkyl phosphites using sodium hydride. 2-Substituted and 1,2-disubtituted β-amino phosphonates have efficiently been prepared following this method. The products are formed in high yield (79-84%) within 8-12 h.