53449-58-4 Usage
Originator
Bled, Poli, Italy ,1978
Manufacturing Process
To a solution of 142 g (1 mol) of trans-3,3,5-trimethylcyclohexanol in 400 cc
of anhydrous benzene heated to 70 C is added gradually 178 g (1 mol) of
niacin chloride hydrochloride. Heating is carried out under reflux conditions for
3 hours, the solution is cooled, the ester hydrochloride is filtered off and then
recrystallized in an ethanol-ethyl ether mixture to obtain 227 g (80% yield) of
product melting at 155°C to 157°C.By treating the hydrochloride with an aqueous solution of NaOH at 0°C, the
free base is obtained in the form of a viscous white liquid which boils at 115°C
under 0.05 mm.
Therapeutic Function
Vasodilator
Check Digit Verification of cas no
The CAS Registry Mumber 53449-58-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,4,4 and 9 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 53449-58:
(7*5)+(6*3)+(5*4)+(4*4)+(3*9)+(2*5)+(1*8)=134
134 % 10 = 4
So 53449-58-4 is a valid CAS Registry Number.
InChI:InChI=1/C15H21NO2/c1-11-7-13(9-15(2,3)8-11)18-14(17)12-5-4-6-16-10-12/h4-6,10-11,13H,7-9H2,1-3H3/t11-,13-/m1/s1
53449-58-4Relevant articles and documents
Cosmetic composition
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, (2008/06/13)
Compositions containing an ester of nicotinic acid and a cosmetically acceptable surfactant are provided. These compositions, when applied topically to the human body produce a response such as a sensory or therapeutic response, for example a tingling or warming sensation or an increase in blood flow, which persists after the composition is rinsed from the body. The compositions are particularly suitable for application to the hair and/or scalp where they may encourage hair growth. Compositions for application to the hair and/or scalp preferably additionally comprise hair benefit agents such as hair growth promoters.
