5345-46-0

Basic information

• Product Name: 5-ACENAPHTHENECARBOXALDEHYDE 95
• Synonyms: 5-ACENAPHTHENECARBOXALDEHYDE 95;5-ACENAPHTHENECARBOXALDEHYDE,98%;1,2-dihydroacenaphthylene-5-carbaldehyde;5-acenaphthylenecarboxaldehyde, 1,2-dihydro-;1,2-dihydroacenaphthylene-5-carbaldehyde(SALTDATA: FREE);acenaphthene-5-carbaldehyde
• CAS NO: 5345-46-0
• Molecular Formula: C₁₃H₁₀O
• Molecular Weight: 182.22
• Product Categories: Aldehydes;C10 to C21;Carbonyl Compounds
• Mol File: 5345-46-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 102-106 °C(lit.)
• Boiling Point: 367.2°Cat760mmHg
• Flash Point: 243.6°C
• Appearance: /
• Density: 1.243g/cm³
• Vapor Pressure: 1.39E-05mmHg at 25°C
• Refractive Index: 1.728
• CAS DataBase Reference: 5-ACENAPHTHENECARBOXALDEHYDE 95(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ACENAPHTHENECARBOXALDEHYDE 95(5345-46-0)
• EPA Substance Registry System: 5-ACENAPHTHENECARBOXALDEHYDE 95(5345-46-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 5345-46-0(Hazardous Substances Data)

Usage

General Description

5-Acenaphthene-carboxaldehyde 95 is a chemical compound commonly used as a reagent in organic synthesis. It is a yellow crystalline solid with a strong odor, and is primarily used as an intermediate in the production of dyes and other organic compounds. It is also used in the manufacturing of pharmaceuticals, agrochemicals, and other specialty chemicals. Additionally, 5-Acenaphthene-carboxaldehyde 95 has been found to have some potential applications in the field of materials science, particularly in the development of new polymers and advanced materials with unique properties. 5-ACENAPHTHENECARBOXALDEHYDE 95 is known to be toxic if ingested, inhaled, or absorbed through the skin, and should be handled with appropriate caution and safety measures.

InChI:InChI=1/C13H10O/c14-8-11-7-6-10-5-4-9-2-1-3-12(11)13(9)10/h1-3,6-8H,4-5H2

Upstream product

• 83-32-9 acenaphthene 
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• 68-12-2 N,N-dimethyl-formamide 
• 95-50-1 1,2-dichloro-benzene 
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• 7446-70-0 aluminium trichloride 
• 74-90-8 hydrogen cyanide 
• 630-20-6 1,1,1,2-tetrachoroethane 
• 77144-97-9 1,3-bis-(trifluoroacetyl)-2-(5-acenaphthyl)-4-imidazoline 
• 4483-79-8 chloromethylene-formamidine 

Downstream Products

• 107641-27-0 [1-Acenaphthen-5-yl-meth-(E)-ylidene]-(4-chloro-phenyl)-amine 
• 107641-26-9 acenaphthen-5-ylmethylen-aniline 
• 1402134-87-5 C₄₀H₃₉CuN₅O₂⁽²⁺⁾ 
• 1402091-16-0 C₄₀H₃₉N₅O₂ 
• 103051-20-3 trans-1-(Biphenylyl-⁽⁴⁾)-2-(acenaphthyl-⁽⁵⁾)-ethylen 
• 13936-09-9 Trans-1-Phenyl-2--aethylen 
• 120870-22-6 N-[4-(5-Acenaphthen-5-yl-3-phenyl-4,5-dihydro-pyrazole-1-sulfonyl)-phenyl]-acetamide 

Relevant articles and documents

Design, Synthesis, and Biological Evaluation of Mitochondria-Targeted Flavone-Naphthalimide-Polyamine Conjugates with Antimetastatic Activity

Approximately 90% of cancer-associated deaths result from disseminated tumors, indicating the ineffectiveness of current therapies and the imperative need of antimetastatic drugs. A novel pharmacophore with flavonoid and naphthalimide moieties was constructed by using a fragment-based drug design and a series of eight flavone-naphthalimide-polyamine conjugates were synthesized. In vitro evaluation revealed that compound 6c with a homospermidine motif displayed better cell selectivity between cancerous and normal liver cells than amonafide did. The in vivo assays on two hepatocellular carcinoma (HCC) models verified that 6c potently suppressed pulmonary metastasis with improved organ indexes compared to amonafide. Various experiments showed that 6c as a potential fluorescent chemical probe could target the mitochondria. Preliminary investigation into the mechanism of action of 6c indicated that it might harness a polyamine transporter for cell entrance, localize in the mitochondria, selectively cause reactive oxygen species (ROS) overproduction in hepatoma cells instead of normal liver cells, and finally lead to HCC cell apoptosis and migration inhibition via multiple ROS-mediated signaling pathways.

A reactive cysteine probe and its preparation method (by machine translation)

The invention discloses a reactive cysteine probe and its preparation method, in order to rhodamine derivative is a fluorophore, acrylic ester structure is a cysteine specific reactive group; probe itself fluorescence is extremely weak, strong fluorescent after reaction with cysteine, can be used for detection of the cysteine. The probe in PBS 7.4 (30% ethanol) system in half-cystine reaction is more rapid, has good selectivity and higher sensitivity; can be used to determine in biological and environmental system of the cysteine content of the fluorescence detection, visual qualitative detection, cell imaging detection. (by machine translation)

Reactive sulfhydryl compound probe and preparation method thereof

The invention discloses a reactive sulfhydryl compound probe and a preparation method of the probe. A sensing molecule releases a rhodamine dye molecule monomer based on a thiol participated disulfide bond cleavage reaction, the fluorescence intensity is significantly improved, an obvious color change is accompanied, and selected interfering ions and the like almost have no influence on a detection effect, so that specific recognition response to a sulfhydryl compound is realized, and a detection limit reaches 0.124 micrometers.